Equilibrium, Kinetic and Structural Properties of Gallium(III) and Some Divalent Metal Complexes Formed with the New DATAm and DATA5m Ligands

Chemistry : a European Journal
Edit FarkasZsolt Baranyai

Abstract

The development of 68 Ge/68 Ga generators has made the positron-emitting 68 Ga isotope widely accessible and raised interest in new chelate complexes of Ga3+ . The hexadentate 1,4-di(acetate)-6-methyl[amino(methyl)acetate]perhydro-1,4-diazepane (DATAm ) ligand and its bifunctional analogue, 1,4-di(acetate)-6-pentanoic acid[amino(methyl)acetate]perhydro-1,4-diazepane (DATA5m ), rapidly form complexes with 68 Ga in high radiochemical yield. The stability constants of DATAm and DATA5m complexes formed with Ga3+ , Zn2+ , Cu2+ , Mn2+ and Ca2+ have been determined by using pH potentiometry, spectrophotometry (Cu2+ ) and 1 H and 71 Ga NMR spectroscopy (Ga3+ ). The stability constants of Ga(DATAm ) and Ga(DATA5m ) complexes are slightly higher than those of Ga(AAZTA). The species distribution calculations indicated the predominance of Ga(L)OH mixed-hydroxo complexes at physiological pH. The 1 H and 71 Ga NMR spectroscopy studies provided information about the coordinated functional groups of ligands and on the kinetics of exchange between the Ga(L) and Ga(L)OH complexes. The transmetalation reactions between the Ga(L) complexes and Cu2+ citrate (6<pH<8.5) occur through both spontaneous and OH- -assisted dissociation of the Ga(L)OH spec...Continue Reading

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Citations

Mar 13, 2019·Dalton Transactions : an International Journal of Inorganic Chemistry·Cinzia ImbertiPhilip J Blower
Nov 23, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Divya YadavChandrasekhar Bal
Oct 30, 2019·EJNMMI Radiopharmacy and Chemistry·Jean-Philippe SinnesFrank Rösch
Nov 14, 2020·Chemistry : a European Journal·Flávio Vinicius Crizóstomo KockZsolt Baranyai
Jun 26, 2021·Bioconjugate Chemistry·Tilmann GrusFrank Roesch
Nov 1, 2018·Chemical Reviews·Thomas I Kostelnik, Chris Orvig

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