Equilibrium water and solute uptake in silicone hydrogels

Acta Biomaterialia
D E LiuC J Radke

Abstract

Equilibrium water content of and solute partitioning in silicone hydrogels (SiHys) are investigated using gravimetric analysis, fluorescence confocal laser-scanning microscopy (FCLSM), and back extraction with UV/Vis-absorption spectrophotometry. Synthesized silicone hydrogels consist of silicone monomer, hydrophilic monomer, cross-linking agent, and triblock-copolymer macromer used as an amphiphilic compatibilizer to prevent macrophase separation. In all cases, immiscibility of the silicone and hydrophilic polymers results in microphase-separated morphologies. To investigate solute uptake in each of the SiHy microphases, equilibrium partition coefficients are obtained for two hydrophilic solutes (i.e., theophylline and caffeine dissolved in aqueous phosphate-buffered saline) and two oleophilic solutes (i.e., Nile Red and Bodipy Green dissolved in silicone oil), respectively. Measured water contents and aqueous-solute partition coefficients increase linearly with increasing solvent-free hydrophilic-polymer volume fraction. Conversely, oleophilic-solute partition coefficients decrease linearly with rising solvent-free hydrophilic-polymer volume fraction (i.e., decreasing hydrophobic silicone-polymer fraction). We quantitatively ...Continue Reading

References

Apr 1, 1995·Biophysical Journal·E M JohnsonW M Deen
Mar 1, 1996·Biophysical Journal·J Tong, J L Anderson
Feb 14, 1998·Optometry and Vision Science : Official Publication of the American Academy of Optometry·L AlvordL Winterton
Mar 27, 2001·Optometry and Vision Science : Official Publication of the American Academy of Optometry·M CoveyB A Holden
Nov 10, 2001·Biomaterials·J L CourtP W Stratford
Nov 10, 2001·Biomaterials·P C Nicolson, J Vogt
Nov 17, 2001·Biomacromolecules·F HorkayP J Basser
Mar 19, 2004·Journal of Colloid and Interface Science·Matthew J Lazzara, William M Deen
Jul 31, 2012·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·Colin CerretaniC J Radke
Sep 24, 2013·Investigative Ophthalmology & Visual Science·Lyndon JonesUNKNOWN members of the TFOS International Workshop on Contact Lens Discomfort
Oct 24, 2013·Biomaterials·Thomas J DurschClayton J Radke

❮ Previous
Next ❯

Citations

Aug 28, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·D E LiuC J Radke
Jan 25, 2018·Journal of Functional Biomaterials·Eneko LarrañetaRyan F Donnelly
May 21, 2019·Journal of Biomaterials Science. Polymer Edition·Hsiu-Wen Chien, Chia-Jung Kuo
Dec 1, 2017·Analytical Biochemistry·Ramachandram BaduguJoseph R Lakowicz

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.