PMID: 7801429Sep 1, 1994Paper

Equine glucose-6-phosphate dehydrogenase deficiency

Veterinary Pathology
S L StockhamD A Kinden

Abstract

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a well-characterized X-linked inherited disorder in humans but has not been reported in horses. We describe a persistent hemolytic anemia and hyperbilirubinemia due to a severe G6PD deficiency in an American Saddlebred colt. Other abnormalities in the colt's erythrocytes as compared with those of healthy horses (n = 22-35) included increased activities of hexokinase and pyruvate kinase, decreased concentrations of reduced glutathione and reduced nicotinamide adenine dinucleotide phosphate (NADP), and increased concentration of oxidized NADP. Morphologic abnormalities included eccentrocytosis, pyknocytosis, anisocytosis, macrocytosis, and increased number of Howell-Jolly bodies. Scanning and transmission electron microscopic examinations revealed that eccentrocytes had contracted to spherical regions and thin collapsed regions. Eccentrocytes were more electron dense than were normal erythrocytes when examined by transmission electron microscopy. When exposed to acetylphenylhydrazine, erythrocytes from the G6PD-deficient colt produced more and smaller Heinz bodies than did erythrocytes from normal horses. Abnormalities in the colt's dam included presence of eccentrocytes and ...Continue Reading

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Citations

Nov 15, 2011·European Journal of Applied Physiology·Mirit EynanAmir Abramovich
Jan 1, 1994·Veterinary Clinical Pathology·William J. ReaganJohn Turek
May 1, 1996·European Journal of Clinical Chemistry and Clinical Biochemistry : Journal of the Forum of European Clinical Chemistry Societies·A MoscaR Galanello
Feb 26, 2004·Proceedings of the National Academy of Sciences of the United States of America·Terje RaudseppBhanu P Chowdhary
Sep 1, 1996·The Veterinary Clinics of North America. Small Animal Practice·J W Harvey
Apr 4, 2007·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Alan T LoynachanJ F Freestone
Apr 13, 2005·American Journal of Veterinary Research·Wendy PearsonMichael I Lindinger
May 5, 2021·Antimicrobial Agents and Chemotherapy·Mingming LiuXuenan Xuan

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