Equine Infectious Anemia Virus (EIAV): what has HIV's country cousin got to tell us?

Veterinary Research
Caroline LerouxR C Montelaro

Abstract

Equine Infectious Anemia Virus (EIAV) is a lentivirus, of the Retrovirus family, with an almost worldwide distribution, infecting equids. It causes a persistent infection characterized by recurring febrile episodes associating viremia, fever, thrombocytopenia, and wasting symptoms. The disease is experimentally reproducible by inoculation of Shetland ponies or horses with EIAV pathogenic strains. Among lentiviruses, EIAV is unique in that, despite a rapid virus replication and antigenic variation, most animals progress from a chronic stage characterized by recurring peaks of viremia and fever to an asymptomatic stage of infection. The inapparent carriers remain infective for life, as demonstrated by experimental transfer of blood to naive animals. The understanding of the correlates of this immune control is of great interest in defining vaccine strategies. Research on EIAV, this "country cousin" of HIV (Human Immunodeficiency Virus), over the last five decades has produced some interesting results on natural immunological control of lentivirus replication and disease and on the nature and role of virus variation in persistence and pathogenesis. These studies are of interest in the context of HIV and efforts to develop a vaccin...Continue Reading

Citations

Dec 29, 2005·AIDS Research and Human Retroviruses·Huiguang LiYiming Shao
Sep 10, 2011·AIDS Research and Human Retroviruses·Koen K A Van Rompay
Apr 21, 2011·Acta Crystallographica. Section F, Structural Biology and Crystallization Communications·Pei Long SunXin Qi Liu
Oct 25, 2008·Virology Journal·Gerard Kian-Meng GohVladimir N Uversky
Jun 21, 2013·PloS One·Jodi K CraigoRonald C Montelaro
Nov 4, 2011·Viruses·Stéphanie Durand, Andrea Cimarelli
Jun 2, 2012·Genetics and Molecular Research : GMR·E M SantosJ K P Reis
May 22, 2009·Journal of Virology·Jörg ZielonkaCarsten Münk
Nov 26, 2008·Nature Structural & Molecular Biology·Kanchan AnandMatthias Geyer
Nov 30, 2016·Archives of Virology·Dellane Martins TigreSilvia Ines Sardi
Mar 12, 2016·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Roberto NardiniMaria Teresa Scicluna
Apr 14, 2016·Veterinary Microbiology·Sonia RicottiAdriana Soutullo
Jul 18, 2017·Human Gene Therapy Methods·Elena Herrera-CarrilloBen Berkhout
Aug 18, 2017·Human Gene Therapy Methods·Michael WhiteElizabeth A Stoll
Apr 17, 2015·Journal of Virology·Elissa J SchwartzRobert H Mealey
Jan 5, 2013·The Open AIDS Journal·Missa P SanouJanet K Yamamoto
May 11, 2019·Biomolecules·Gerard Kian-Meng GohVladimir N Uversky
Jun 7, 2012·Cellular and Molecular Life Sciences : CMLS·Nolwenn Jouvenet
Jul 28, 2011·Journal of Mathematical Biology·John Lang, Michael Y Li
Oct 29, 2011·Cellular and Molecular Life Sciences : CMLS·Bin XueVladimir N Uversky
Aug 30, 2013·Parasite : Journal De La Société Française De Parasitologie·Frédéric BaldacchinoGérard Duvallet

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