Equine laminitis: ultrastructural lesions detected in ponies following hyperinsulinaemia

Equine Veterinary Journal
A R NourianC C Pollitt

Abstract

Anatomical changes in the hoof lamellar tissue induced by prolonged hyperinsulinaemia have not been described previously. Analysis of the induced lesions may promote understanding of hyperinsulinaemic laminitis pathogenesis and produce clinical benefit. To use light and transmission electron microscopy (TEM) to document hoof lamellar lesions in ponies clinically lame after prolonged hyperinsulinaemia. Nine clinically normal, mature ponies were allocated randomly to either a treatment group (n = 5) or control group (n = 4). The treatment group received insulin via a modified, prolonged euglycaemic hyperinsulinaemic clamp technique (EHCT) and were subjected to euthanasia when clinical signs of Obel grade II laminitis occurred. The control group was sham treated with an equivalent volume of 0.9% saline and killed at 72 h. Lamellar tissues of the right front feet were harvested and processed for TEM. Lamellae from insulin treated ponies were attenuated and elongated with many epidermal basal cells (EBC) in mitosis. Unlike carbohydrate induced laminitis in horses there was no global separation at the lamellar dermal/epidermal interface among ponies. Sporadic EBC basement membrane (BM) separation was associated with the proximity of ...Continue Reading

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Citations

Dec 3, 2014·The Veterinary Journal·Claire UnderwoodChristopher C Pollitt
Aug 27, 2014·American Journal of Veterinary Research·Bianca Patan-ZugajTheresia F Licka
Feb 27, 2013·Journal of Equine Veterinary Science·Richard J JohnsonTanja Hess
Jan 14, 2012·Veterinary Immunology and Immunopathology·M A de LaatC C Pollitt
Nov 1, 2011·The Veterinary Journal·Patricia Harris
Aug 13, 2011·Veterinary Immunology and Immunopathology·Michelle B Visser, Christopher C Pollitt
Sep 6, 2011·Veterinary Immunology and Immunopathology·Rafael R FaleirosJames K Belknap
Jul 27, 2010·The Veterinary Journal·Geoffroy de la Rebière de Pouyade, Didier Serteyn
Aug 12, 2010·The Veterinary Clinics of North America. Equine Practice·Simon R Bailey
Aug 12, 2010·The Veterinary Clinics of North America. Equine Practice·Melody A de LaatChristopher C Pollitt
Aug 12, 2010·The Veterinary Clinics of North America. Equine Practice·Philip J JohnsonNat T Messer
Apr 13, 2010·The Veterinary Clinics of North America. Equine Practice·Christopher C Pollitt, Michelle B Visser
Oct 31, 2012·Equine Veterinary Journal·L M Katz, S R Bailey
Oct 31, 2012·Equine Veterinary Journal·A W van Eps
Feb 17, 2010·Equine Veterinary Journal·M A de LaatC C Pollitt
May 15, 2018·Equine Veterinary Journal·C SandowS Eades
Nov 20, 2019·Toxicologic Pathology·Qingqiu Yang, Mandi J Lopez

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