Equine-Like H3 Avian Influenza Viruses in Wild Birds, Chile.

Emerging Infectious Diseases
Nicolas Bravo-VasquezChristopher Hamilton-West

Abstract

Since their discovery in the United States in 1963, outbreaks of infection with equine influenza virus (H3N8) have been associated with serious respiratory disease in horses worldwide. Genomic analysis suggests that equine H3 viruses are of an avian lineage, likely originating in wild birds. Equine-like internal genes have been identified in avian influenza viruses isolated from wild birds in the Southern Cone of South America. However, an equine-like H3 hemagglutinin has not been identified. We isolated 6 distinct H3 viruses from wild birds in Chile that have hemagglutinin, nucleoprotein, nonstructural protein 1, and polymerase acidic genes with high nucleotide homology to the 1963 H3N8 equine influenza virus lineage. Despite the nucleotide similarity, viruses from Chile were antigenically more closely related to avian viruses and transmitted effectively in chickens, suggesting adaptation to the avian host. These studies provide the initial demonstration that equine-like H3 hemagglutinin continues to circulate in a wild bird reservoir.

References

Jan 1, 1985·Journal of Molecular Evolution·M HasegawaT Yano
Jan 29, 2002·Archives of Virology·E HoffmannD R Perez
Jun 26, 2004·Science·Derek J SmithRon A M Fouchier
Nov 13, 2007·BMC Evolutionary Biology·Alexei J Drummond, Andrew Rambaut
Jul 17, 2009·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Peter P CheungJ S M Peiris
Dec 21, 2010·Bioinformatics·Klaus Peter Schliep
Mar 25, 2011·Journal of Virology·Pablo R MurciaEdward C Holmes
Sep 7, 2013·PLoS Pathogens·Justin BahlRobert G Webster
Jun 4, 2014·Annals of the New York Academy of Sciences·Robert G Webster, Elena A Govorkova
Jul 10, 2014·Current Topics in Microbiology and Immunology·Robert E KahnJürgen A Richt
Apr 1, 2013·Emerging Microbes & Infections·Erik A KarlssonStacey Schultz-Cherry
Jan 20, 2016·PloS One·Martha I NelsonDaniel G Bausch
Jul 19, 2016·Influenza and Other Respiratory Viruses·Udayan JosephGavin J D Smith
Dec 8, 2016·Emerging Microbes & Infections·Pedro Jiménez-BluhmJorge E Osorio
Mar 30, 2018·Emerging Microbes & Infections·Pedro Jiménez-BluhmStacey Schultz-Cherry
Feb 5, 2019·The Journal of Infectious Diseases·Gabriele Neumann, Yoshihiro Kawaoka
Mar 30, 2019·Emerging Microbes & Infections·Pedro Jimenez-BluhmChristopher Hamilton-West

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Methods Mentioned

BETA
reverse transcription PCR

Software Mentioned

ggtree
R
GraphPad Prism
BEAST
BLAST
FigTree
CD
PHANGORN
EST
treeannotator

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