Equine tetherin blocks retrovirus release and its activity is antagonized by equine infectious anemia virus envelope protein.

Journal of Virology
Xin YinXiaojun Wang

Abstract

Human tetherin is a host restriction factor that inhibits replication of enveloped viruses by blocking viral release. Tetherin has an unusual topology that includes an N-terminal cytoplasmic tail, a single transmembrane domain, an extracellular domain, and a C-terminal glycosylphosphatidylinositol anchor. Tetherin is not well conserved across species, so it inhibits viral replication in a species-specific manner. Thus, studies of tetherin activities from different species provide an important tool for understanding its antiviral mechanism. Here, we report cloning of equine tetherin and characterization of its antiviral activity. Equine tetherin shares 53%, 40%, 36%, and 34% amino acid sequence identity with feline, human, simian, and murine tetherins, respectively. Like the feline tetherin, equine tetherin has a shorter N-terminal domain than human tetherin. Equine tetherin is localized on the cell surface and strongly blocks human immunodeficiency virus type 1 (HIV-1), simian immunodeficiency virus (SIV), and equine infectious anemia virus (EIAV) release from virus-producing cells. The antiviral activity of equine tetherin is neutralized by EIAV envelope protein, but not by the HIV-1 accessory protein Vpu, which is a human tet...Continue Reading

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Citations

May 2, 2014·Frontiers in Microbiology·Daniel Sauter
Nov 20, 2013·Current Opinion in Virology·Klaus Strebel
Dec 3, 2014·The Veterinary Clinics of North America. Equine Practice·Charles J IsselDavid W Horohov
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Nov 5, 2015·Scientific Reports·Junko S TakeuchiKei Sato
Sep 12, 2014·Journal of Virology·Cécile LemaîtreMarie Dewannieux
Mar 14, 2014·Journal of Virology·Julia Weinelt, Stuart J D Neil
Feb 2, 2019·Reviews in Medical Virology·Anshika Sharma, Sunil K Lal
Feb 9, 2018·Oncotarget·Hua-Nan WangJian-Guo Dong

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