Equine viral vaccines: the past, present and future

Veterinary Research
Jules Maarten MinkeLaurent Fischer

Abstract

The increasing international movement of horses combined with the relaxation of veterinary regulations has resulted in an increased incidence of equine infectious diseases. Vaccination, along with management measures, has become the primary method for the effective control of these diseases. Traditionally modified live and inactivated vaccines have been used and these vaccines have proven to be very successful in preventing disease. However, there are a number of equine infectious diseases for which conventional technology has shown its limitations. The advent of recombinant technology has stimulated the development of second generation vaccines, including gene deleted mutants, live vectored vaccines and DNA vaccines. These vaccines have in common that protective antigens are endogenously processed and presented along the molecules of the MHC I and MHC II complex, resulting in the stimulation of both humoral and cell-mediated immune responses similar to natural infection. The present paper provides a review of the vaccines being employed today against the most important equine viral diseases followed by a summary of new developments that are expected to bring improved vaccines to the market in the foreseeable future.

Citations

Mar 23, 2012·Animal Health Research Reviews·Ryan L Vander VeenKurt I Kamrud
Nov 9, 2005·Clinical and Diagnostic Laboratory Immunology·Kemal KaracaRobert Nordgren
Jul 17, 2007·Clinical Microbiology Reviews·Els N T MeeusenGregers Jungersen
Jun 4, 2010·Journal of Virology·Joy GardnerAndreas Suhrbier
Feb 5, 2011·Virology Journal·Simon C Weli, Morten Tryland
Nov 6, 2008·Acta Veterinaria Scandinavica·Gudbjörg OlafsdóttirSigurbjörg Torsteinsdóttir
Dec 19, 2012·Journal of Pharmacy & Bioallied Sciences·Sameer Sharma, Lyn A Hinds
Aug 12, 2014·Viruses·Ralph A Tripp, S Mark Tompkins
Apr 9, 2015·Viruses·Lucas Sánchez-SampedroMariano Esteban
Oct 26, 2006·Journal of Veterinary Medicine. B, Infectious Diseases and Veterinary Public Health·C M GalosiE J Gimeno
Nov 24, 2012·Microbiology·Manvendra SaxenaPeter M Smooker
Dec 5, 2009·The Journal of Veterinary Medical Science·Koji TSUJIMURATomio MATSUMURA
Oct 29, 2014·Australian Veterinary Journal·K TabynovA Sansyzbay
Jan 10, 2014·Revista Argentina de microbiología·Guillermo H SguazzaMarcelo R Pecoraro
Jan 27, 2015·Veterinary Immunology and Immunopathology·D W HorohovT M Chambers
Dec 12, 2018·Journal of Medical Entomology·Lucy L RobbRebekah C Kading
Feb 3, 2006·Expert Review of Vaccines·Cristina T RosasNikolaus Osterrieder
Aug 15, 2012·Equine Veterinary Journal·J H KyddB Wagner
Jun 7, 2019·Journal of the South African Veterinary Association·Lara J BrownMartin L Schulman
Aug 9, 2006·The Journal of General Virology·Julia H KyddShirley A Ellis
Apr 24, 2021·Vaccine·Benjamin C PiersonMaryam Keshtkar Jahromi
May 24, 2021·Cell & Bioscience·Zhilong YangLake Winter
Jun 3, 2021·Animal Health Research Reviews·Luís DionísioAna I Faustino-Rocha
Aug 29, 2021·Viruses·Fatai S OladunniThomas M Chambers
Jul 26, 2008·The Veterinary Clinics of North America. Equine Practice·Kurt L Zimmerman, Mark V Crisman

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.