Abstract
Converting enzyme inhibitors are more effective than arteriolar vasodilators at regressing left ventricular hypertrophy in spontaneously hypertensive rats (SHR), possibly because of nonhemodynamic factors. However, the pulsatile component of hemodynamic load has not been evaluated in this model. We measured pulsatile hemodynamics in 18-month-old male SHR after 6 months of therapy with either zofenopril (Z), hydralazine (H), or water (W). Hydralazine and zofenopril reduced mean arterial pressure comparably (W, 106 +/- 23 versus H, 81 +/- 12 versus Z, 84 +/- 18 mm Hg, P = .002) yet had a differential effect on the ratio of left ventricular weight to body weight (W, 3.9 +/- 0.5 versus H, 3.3 +/- 0.4 versus Z, 2.4 +/- 0.2 g/kg, P < .005). Hydralazine-treated SHR had increased characteristic impedance (P = .0011) and a persistently low ratio of the reflected-wave transit time to left ventricular ejection time (P < .001), which contributed to early and late systolic loading, respectively, of the left ventricle. Consequently, only zofenopril-treated SHR had a significant reduction in left ventricular systolic force-time integral (P = .02), a measure of total ventricular load. There were no differences in systolic stress-time integral,...Continue Reading
References
Sep 1, 1977·Cardiovascular Research·S SenF M Bumpus
Mar 1, 1978·IEEE Transactions on Bio-medical Engineering·S LaxminarayanN Westerhof
Jun 1, 1992·Journal of the American College of Cardiology·A GanauJ H Laragh
Mar 1, 1991·Annals of Internal Medicine·M J KorenJ H Laragh
Oct 1, 1991·American Heart Journal·X GirerdM Safar
May 31, 1990·The New England Journal of Medicine·D LevyW P Castelli
Nov 1, 1990·Hypertension·M ClozelF Hefti
Apr 1, 1990·Hypertension·M O'Rourke
Feb 1, 1989·Journal of Hypertension·B PannierM E Safar
Feb 1, 1985·Japanese Circulation Journal·H Maeta, M Hori
Apr 1, 1988·Hypertension·J Tsoporis, F H Leenen
Feb 1, 1989·Journal of the American College of Cardiology·R N IsnardM E Safar
Aug 1, 1986·Annals of Internal Medicine·P N CasaleJ H Laragh
Dec 1, 1988·Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension·B I LevyM E Safar
Jun 1, 1985·American Heart Journal·J D BouthierA C Simon
Oct 1, 1986·The American Journal of Physiology·V E Baracos, A L Goldberg
Feb 1, 1987·Hypertension·G K Owens
Jan 1, 1986·Journal of Biomechanics·D L NewmanN Westerhof
Feb 1, 1986·Journal of Hypertension·P FribergM Nordlander
Apr 15, 1985·The American Journal of Cardiology·W W NicholsC R Conti
Oct 19, 1972·The New England Journal of Medicine·W B KannelM Feinleib
Jul 6, 1972·The New England Journal of Medicine·W R Milnor
Jan 1, 1984·Journal of Cardiovascular Pharmacology·M A Pfeffer, J M Pfeffer
Jul 1, 1983·Journal of Cardiovascular Pharmacology·A C SimonA Benetos
Apr 1, 1982·European Heart Journal·J P MerillonR Gourgon
May 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·J M PfefferE Braunwald
Sep 26, 1983·The American Journal of Medicine·W B Kannel
Jan 1, 1984·The American Journal of Physiology·R Takemura, Z Werb
Oct 1, 1980·The American Journal of Medicine·W Grossman
May 1, 1980·Cardiovascular Research·P SipkemaO S Randall
May 1, 1995·American Journal of Hypertension·R J CodyD M Brown
Dec 1, 1993·Journal of the American College of Cardiology·P S SabaR B Devereux
Jan 1, 1994·Hypertension·P AlbaladejoA Benetos
Jun 24, 1993·The American Journal of Cardiology·P GohlkeT Unger
Sep 1, 1995·Journal of Hypertension·N Westerhof, M F O'Rourke
Citations
Jul 10, 1999·Biulleten' eksperimental'noĭ biologii i meditsiny·V A FrolovP Rieger
Sep 18, 2007·Pflügers Archiv : European journal of physiology·Hsing I ChenCheng-Tao Hu
Oct 15, 2008·Medical & Biological Engineering & Computing·Gary F Mitchell
Sep 12, 2000·Current Hypertension Reports·C Vlachopoulos, M O'Rourke
Nov 6, 2004·Current Hypertension Reports·Gary F Mitchell
Mar 7, 2001·European Journal of Pharmacology·G SaccoC A Maggi
Mar 27, 2001·Journal of the American College of Cardiology·A M Dart, B A Kingwell
Dec 31, 1997·Journal of the American College of Cardiology·C S Hayward, R P Kelly
Mar 26, 1999·Journal of the American College of Cardiology·M J DomanskiM A Pfeffer
Dec 10, 1998·Trends in Microbiology·R J North, E Medina
Aug 24, 1999·British Journal of Pharmacology·N SaadaneL E Chalifour
Jul 15, 2000·The New England Journal of Medicine·J W Weinsaft
Dec 30, 1998·Journal of Cardiovascular Pharmacology·T NguyenJ L Rouleau
May 5, 2001·Journal of Cardiovascular Pharmacology·W F HeesenK I Lie
Apr 16, 1998·Canadian Journal of Physiology and Pharmacology·L S MatsubaraA C Cicogna
Jun 3, 2010·Circulation. Heart Failure·Dalane W KitzmanWilliam C Little
Jul 30, 2008·Hypertension·Erik IngelssonRamachandran S Vasan
Sep 29, 1999·Current Opinion in Cardiology·G F Mitchell, M A Pfeffer
Aug 31, 1999·Journal of Hypertension·J A MillarV Burke
Feb 18, 2005·Journal of Hypertension·Kozo HirataMichael F O'Rourke
Sep 30, 2009·Journal of Cardiac Failure·Akshay S DesaiMark A Creager
Feb 18, 2010·Artery Research·Gary F Mitchell
Sep 29, 2005·European Journal of Heart Failure·Gary F MitchellMarc A Pfeffer
May 17, 2005·American Heart Journal·Gary F Mitchell, Marc A Pfeffer
May 24, 2000·Current Problems in Cardiology·C Vlachopoulos, M O'rourke
Aug 14, 2003·The American Journal of Cardiology·Anil NigamJean-Claude Tardif
Jul 15, 2015·Current Hypertension Reports·Vanessa Bell, Gary F Mitchell
Jul 6, 2015·Current Hypertension Reports·Gary F Mitchell
Apr 30, 2008·Diabetes Care·Piero RuggenentiUNKNOWN Bergamo Nephrologic Diabetes Complications Trial Study Group
Jan 18, 2005·The Journal of International Medical Research·S Evangelista, S Manzini
Jul 24, 2018·The Journal of Clinical Hypertension·Tetsuya TakahashiMasafumi Watanabe
Aug 28, 2004·Expert Opinion on Pharmacotherapy·Claudio BorghiEttore Ambrosioni
Mar 27, 2003·Journal of Hypertension·Jeanette WoolardMichael A Adams
Aug 19, 2003·Journal of Hypertension·Antti KuoppalaJorma O Kokkonen
Mar 10, 2000·American Journal of Physiology. Heart and Circulatory Physiology·H MiyashitaK Sunagawa
Dec 16, 1998·The Medical Journal of Australia·P S Macdonald, M F O'Rourke