Equivalence of autoadjusted and constant continuous positive airway pressure in home treatment of sleep apnea

Chest
Yvonne NussbaumerRobert Thurnheer

Abstract

Whether computerized autoadjusted continuous positive airway pressure (aCPAP) is effective or even superior to constant continuous positive airway pressure (cCPAP) in the treatment of obstructive sleep apnea syndrome (OSAS) is still controversial. We performed a randomized, double-blind, controlled, cross-over trial comparing efficacy of sleep apnea home therapy by a novel aCPAP machine (REMStarAuto; Respironics; Murrysville, PA) operated in autoadjusted or constant mode. Thirty sleep apnea patients were recruited consecutively. Mean baseline Epworth sleepiness scale (ESS) score was 12.7 +/- 0.6 (+/- SD), mean sleep resistance time was 26 +/- 2 min (Osler test; Stowood Scientific Systems; Oxford, UK), and mean apnea-hypopnea index (AHI) was 41.1 +/- 3.6 h. Patients were randomly assigned to 1 month of home therapy with aCPAP followed by 1 month with cCPAP, or vice versa. After 1 month with treatment, the mean ESS score, sleep resistance time, and AHI were significantly improved (6.6 +/- 0.6, 37 +/- 1 min, and 4.6 +/- 0.7 h, respectively; all p < 0.05 vs baseline). Similar effects were achieved with cCPAP (p = not significant vs aCPAP). Twenty-six patients preferred aCPAP, and 4 patients preferred cCPAP (p < 0.001). We conclude ...Continue Reading

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Citations

Sep 24, 2010·Sleep & Breathing = Schlaf & Atmung·Patrícia Caetano MotaJosé Agostinho Marques
Apr 27, 2007·The New England Journal of Medicine·Robert C Basner
Aug 24, 2011·Expert Review of Respiratory Medicine·Robert Thurnheer
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Dec 17, 2014·Sleep & Breathing = Schlaf & Atmung·Sandra RebeloJosé Agostinho Marques
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Oct 13, 2009·The Cochrane Database of Systematic Reviews·Ian Smith, Toby J Lasserson
Apr 21, 2021·Archivos de bronconeumología·Olga MedianoUNKNOWN el Spanish Sleep Network

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