PMID: 6169424Oct 15, 1981Paper

Equivalence of radiation schedules for the palliative treatment of brain metastases in patients with favorable prognosis

Cancer
R GelberS Kramer

Abstract

Five whole-brain irradiation schedules ranging from 2000 rad in one week to 4000 rad in four weeks were evaluated in 1830 patients with cerebral metastases treated in two randomized studies by the Radiation Therapy Oncology Group. The duration of palliative effectiveness among those patients with favorable survival prognosis was investigated. Favorable subgroups were identified consisting of 123 ambulatory breast cancer patients with no soft tissue metastases, 373 ambulatory lung cancer patients with primary absent or no extracerebral metastases, and 65 ambulatory patients with other primaries and no extracerebral metastases. This group of 561 patients had a median survival of 28 weeks compared with 11 weeks for the remaining patients. Analyses of neurologic function control rates failed to show a significant benefit of higher doses. No advantage was demonstrated for treating brain metastases patients with favorable prognoses with more than one week of whole-brain irradiation.

References

Nov 1, 1979·Cancer·A DiStefanoG R Blumenschein
Jun 1, 1972·Cancer·G S MontanaW L Caldwell
Feb 1, 1971·The American Journal of Roentgenology, Radium Therapy, and Nuclear Medicine·L Z NisceF C Chu
Jan 1, 1980·International Journal of Radiation Oncology, Biology, Physics·B BorgeltF R Hendrickson
Jul 1, 1954·Cancer·J H CHAOJ J NICKSON

❮ Previous
Next ❯

Citations

Jul 20, 2000·International Journal of Cancer. Journal International Du Cancer·M H MaorS J Hassenbusch
Jan 1, 1987·Journal of Neuro-oncology·G E Sheline, L W Brady
Feb 1, 1993·Journal of Neuro-oncology·W BoogerdG Baris
Feb 4, 2010·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Petra FeyerRolf Sauer
Mar 1, 1994·International Journal of Radiation Oncology, Biology, Physics·J C FlickingerP K Sneed
Sep 16, 1999·International Journal of Radiation Oncology, Biology, Physics·D KondziolkaJ C Flickinger
Nov 26, 1999·International Journal of Radiation Oncology, Biology, Physics·T MatsuoK Hayashi
Oct 23, 2003·Clinical Oncology : a Journal of the Royal College of Radiologists·D WilsonN James
Nov 10, 2000·Breast Cancer Research and Treatment·T FokstuenJ O Fernberg
Nov 28, 2002·Australasian Radiology·Phillip G Yuile, Mai H Tran
Jun 1, 1997·American Journal of Clinical Oncology·M ColleoniP Manente
Jun 11, 2003·American Journal of Clinical Oncology·Mary A HermanMinesh P Mehta
Jan 15, 2004·The Neurologist·Kevin J Klos, Brian Patrick O'Neill
May 1, 1983·Journal of Neurosurgery·N SundaresanE J Beattie
Jul 18, 2014·Journal of the National Cancer Institute·Siow Ming LeeCorinne Faivre-Finn
Jan 1, 1996·Cancer Investigation·R A Patchell
Nov 1, 1994·Mayo Clinic Proceedings·B P O'NeillE G Shaw
Nov 17, 2005·Cancer·Douglas KondziolkaL Dade Lunsford
Nov 30, 2010·Surgical Oncology Clinics of North America·Nikhil G RaoVernon K Sondak
Mar 1, 1989·International Journal of Radiation Oncology, Biology, Physics·M Diener-WestD F Nelson
Jul 1, 1990·International Journal of Radiation Oncology, Biology, Physics·P J HoskinH T Ford
Mar 1, 1991·International Journal of Radiation Oncology, Biology, Physics·K D Schupak, K E Wallner
Jun 21, 2008·Revue neurologique·J-S GuillamoG-L Defer
Dec 8, 2004·Critical Reviews in Oncology/hematology·Alicia TosoniAlba A Brandes
Jun 3, 2004·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Andrew M BroadbentIan Firth
May 1, 1997·Current Problems in Cancer·D Hoegler
Feb 1, 1993·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·C Haie-MederR Arriagada
Jan 5, 2002·Hematology/oncology Clinics of North America·S M Arnold, R A Patchell
Jun 28, 2005·Cancer Treatment Reviews·Renata Duchnowska, Cezary Szczylik
Apr 19, 2005·The Surgical Clinics of North America·Fred G Barker
Aug 25, 2012·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Bjørn H GrønbergStein Sundstrøm
Feb 22, 1990·The New England Journal of Medicine·R A PatchellB Young
Feb 15, 1992·Cancer·W BoogerdJ J van der Sande
Sep 15, 1990·Cancer·I C HendersonJ R Harris
Aug 31, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D AntonadouN Throuvalas

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.