Equivalent and sufficient effects of leuprolide acetate and goserelin acetate to suppress serum testosterone levels in patients with prostate cancer

BJU International
Yasuhisa FujiiIwao Fukui

Abstract

To compare the effects of leuprolide acetate and goserelin acetate for suppressing serum testosterone levels in Japanese patients with prostate cancer, as several recent studies suggested that serum testosterone is not always suppressed below the upper limit of the castration range in patients using luteinizing hormone-releasing hormone (LH-RH) agonists, especially leuprolide acetate. In all, 232 patients with prostate cancer, whose serum testosterone levels were measured before and during treatment using a 1- or 3-monthly formulation of leuprolide or goserelin, were enrolled in a retrospective study. The mean age of the patients was 69.8 years and the mean testosterone level before the LHRH treatment was 4.54 ng/mL. The patients had their testosterone levels assessed a mean (range) of 5.4 (1-35) times during the LHRH treatment. A castrate serum testosterone level was defined as <or= 0.5 ng/mL. The mean maximum testosterone level during 1-monthly leuprolide (40 patients), 3-monthly leuprolide (68), 1-monthly goserelin (50), or 3-monthly goserelin (74) treatment was 0.22, 0.20, 0.19 and 0.20 ng/mL, respectively (not significant). Four patients, including two treated with 1-monthly leuprolide, one with 3-monthly leuprolide and on...Continue Reading

References

Jul 4, 2001·The Journal of Urology·M R Smith, F J McGovern
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Citations

Sep 23, 2014·International Journal of Urology : Official Journal of the Japanese Urological Association·Yosuke YasudaIwao Fukui
Jan 8, 2011·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·S IannazzoM Perachino
Dec 10, 2020·Journal of the Endocrine Society·Mustafa KinaanKenneth Simon
Apr 25, 2009·Current Opinion in Endocrinology, Diabetes, and Obesity

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