Equol and para-ethyl-phenol stimulate prostaglandin F(2alpha) secretion in bovine corpus luteum: intracellular mechanisms of action

Prostaglandins & Other Lipid Mediators
Izabela Woclawek-PotockaDariusz J Skarzynski

Abstract

Corpus luteum (CL) is a reproductive gland that plays a crucial endocrine role in the regulation of the estrous cycle, fertility, and pregnancy in cattle. The main function of CL is secretion of progesterone (P4), an important hormone for establishment a successful pregnancy, whereas prostaglandin F(2alpha) (PGF(2alpha)), 17beta-estradiol (E(2)) and testosterone (T) are implicated in the regulation of luteolysis. It has been shown that phytoestrogens may disrupt numerous reproductive functions on several levels of regulation and via different intracellular mechanisms. Using a cell-culture system of steroidogenic cells of the bovine CL, we determined effects of active phytoestrogen metabolites (equol and para-ethyl-phenol) on PGF(2alpha), P4, and T synthesis in steroidogenic CL cells. Moreover, we examined the intracellular mechanisms of phytoestrogen metabolite actions. Phytoestrogen metabolites did not affect P4 production in steroidogenic CL cells. However, PGF(2alpha) and T were significantly stimulated by metabolites of phytoestrogens in the bovine steroidogenic CL cells. To study the intracellular mechanism of endogenous E(2) and phytoestrogen metabolites action, steroidogenic cells were preincubated with a phospholipase C...Continue Reading

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Citations

Aug 6, 2008·The Journal of Reproduction and Development·Izabela Woclawek-PotockaDariusz Jan Skarzynski
May 28, 2013·International Journal of Endocrinology·Izabela Wocławek-PotockaDariusz J Skarżyński
Aug 1, 2008·Nutrition Reviews·Raewyn C Poulsen, Marlena C Kruger
Apr 3, 2012·Animal Reproduction Science·Horacio Cárdenas, William F Pope
Mar 22, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ludmila KřížováTomáš Kašparovský

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