ER Ca2+ release and store-operated Ca2+ entry - partners in crime or independent actors in oncogenic transformation?

Cell Calcium
Cristina PierroH Llewelyn Roderick

Abstract

Ca2+ is a pleiotropic messenger that controls life and death decisions from fertilisation until death. Cellular Ca2+ handling mechanisms show plasticity and are remodelled throughout life to meet the changing needs of the cell. In turn, as the demands on a cell alter, for example through a change in its niche environment or its functional requirements, Ca2+ handling systems may be targeted to sustain the remodelled cellular state. Nowhere is this more apparent than in cancer. Oncogenic transformation is a multi-stage process during which normal cells become progressively differentiated towards a cancerous state that is principally associated with enhanced proliferation and avoidance of death. Ca2+ signalling is intimately involved in almost all aspects of the life of a transformed cell and alterations in Ca2+ handling have been observed in cancer. Moreover, this remodelling of Ca2+ signalling pathways is also required in some cases to sustain the transformed phenotype. As such, Ca2+ handling is hijacked by oncogenic processes to deliver and maintain the transformed phenotype. Central to generation of intracellular Ca2+ signals is the release of Ca2+ from the endoplasmic reticulum intracellular (ER) Ca2+ store via inositol 1,4,5...Continue Reading

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Citations

Jun 17, 2020·The FEBS Journal·Michela RossiniRiccardo Filadi
May 13, 2020·International Journal of Molecular Sciences·Carlos CantoneroPedro C Redondo
Aug 19, 2020·Redox Biology·Corina T Madreiter-SokolowskiMichael Ristow
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Oct 14, 2019·Cell Calcium·Mathieu GautierHalima Ouadid-Ahidouch
Sep 29, 2021·Cell Communication and Signaling : CCS·Tingting LiZhiyong Zeng

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