ER-Mitochondria Crosstalk during Cerebral Ischemia: Molecular Chaperones and ER-Mitochondrial Calcium Transfer.

International Journal of Cell Biology
Yi-Bing Ouyang, R G Giffard

Abstract

It is commonly believed that sustained elevations in the mitochondrial matrix Ca(2+) concentration are a major feature of the intracellular cascade of lethal events during cerebral ischemia. The physical association between the endoplasmic reticulum (ER) and mitochondria, known as the mitochondria-associated ER membrane (MAM), enables highly efficient transmission of Ca(2+) from the ER to mitochondria under both physiological and pathological conditions. Molecular chaperones are well known for their protective effects during cerebral ischemia. It has been demonstrated recently that many molecular chaperones coexist with MAM and regulate the MAM and thus Ca(2+) concentration inside mitochondria. Here, we review recent research on cerebral ischemia and MAM, with a focus on molecular chaperones and ER-mitochondrial calcium transfer.

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Citations

Dec 11, 2013·Translational Stroke Research·Yi-Bing Ouyang, Rona G Giffard
Mar 16, 2013·Cell Biology International·Marco Fidel AvilaGeorge E Barreto
Jan 1, 2014·Neurochemistry International·Yi-Bing Ouyang, Rona G Giffard
Nov 26, 2013·Neuroscience Letters·Yi-Bing OuyangRona G Giffard
Jan 13, 2015·Biochimica Et Biophysica Acta·Valentina RealiFederica Di Sano
Aug 29, 2019·Annals of the New York Academy of Sciences·Pabbala VeereshPallab Bhattacharya
Dec 24, 2013·Antioxidants & Redox Signaling·Yi-Bing OuyangRona G Giffard
Nov 6, 2014·Science Signaling·Fabian Finger, Thorsten Hoppe
Oct 8, 2020·Metabolites·Haoxin ZhaoStanley Ching-Cheng Huang
Mar 17, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Guokun ZhouXiang-Ming Zha
Apr 4, 2021·Journal of Clinical Medicine·Ji TuAshish D Diwan
May 1, 2021·Archives of Medical Research·Nasrin AbolhasanpourLeila Hosseini
May 8, 2019·Neurotoxicology·Nandkishor Ramdas KotagaleNazma Najirahmad Inamdar

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Methods Mentioned

BETA
protein folding
electron tomography
GTPase

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