ER, PgR, Ki67, p27(Kip1), and histological grade as predictors of pathological complete response in patients with HER2-positive breast cancer receiving neoadjuvant chemotherapy using taxanes followed by fluorouracil, epirubicin, and cyclophosphamide concomitant with trastuzumab

BMC Cancer
Sasagu KurozumiTetsunari Oyama

Abstract

Neoadjuvant chemotherapy (NAC) with taxanes followed by fluorouracil, epirubicin, and cyclophosphamide (FEC), and concurrent trastuzumab is a potent regimen for HER2 over-expressing breast cancer. A high pathological complete response (pCR) rate has been achieved using this regimen; however, the predictive factors and prognostic effects of pCR currently remain unclear. In the present study, we determined whether pCR was related to histological grade (HG) and several biological factors including p27(Kip1). We also assessed the prognosis of the pCR and non-pCR groups, and expected differences between those positive and negative for lymph node metastasis after chemotherapy. A total of 129 Japanese women with HER2-positive invasive breast cancer received either paclitaxel or docetaxel followed by FEC, with the concomitant administration of trastuzumab. The statuses of HG, ER, PgR, Ki67, and p27(Kip1) were evaluated to determine their relationship with pCR. Relapse-free survival (RFS) and overall survival (OS) were also analyzed for their relationship with pCR and pathological nodal involvement. pCR was obtained in 84 out of 129 patients and the pCR rate was 65.1%. The pCR rates related to 5 factors were as follows: HG (grade 3, 70....Continue Reading

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Citations

Dec 17, 2015·Nature Reviews. Clinical Oncology·Peter SavasSherene Loi
Mar 24, 2016·Nature Reviews. Clinical Oncology·Leticia De Mattos-ArrudaJavier Cortés
Oct 12, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Pietro Di FazioAndreas Kirschbaum
Feb 13, 2019·Japanese Journal of Clinical Oncology·Parveen JainVineet Talwar
Sep 9, 2017·Applied Immunohistochemistry & Molecular Morphology : AIMM·Dustin E BoschOliver H Chang
Apr 11, 2018·Breast Cancer Research and Treatment·Sasagu KurozumiEmad A Rakha
Jun 25, 2020·Cancer Metastasis Reviews·Belinda J Petri, Carolyn M Klinge
Nov 15, 2019·Scientific Reports·Sasagu KurozumiKen Shirabe
Mar 14, 2018·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Martin FilipitsUNKNOWN TransHERA investigators
Jun 5, 2020·Seminars in Cancer Biology·Dipta SenguptaSamir Kumar Patra

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Methods Mentioned

BETA
biopsy
dissection

Software Mentioned

Stat Mate

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