ER: the Silk Road of interorganellar communication

Current Opinion in Plant Biology
Jin-Zheng Wang, Katayoon Dehesh

Abstract

Cellular adaptive responses arise from an array of spatially and temporally distinct biochemical interactions that modulate biological processes and reorganize subcellular structures tailored to the nature of stimulus. As such, cells have evolved elegantly and tightly regulated mechanisms to enable interorganellar communication in part through the dynamic readjustment of physical distance enabling the tethering between two closely apposed membranous organelles and thus formation of Membrane Contact Sites (MCSs). MCSs are dynamic and ubiquitous interorganellar structures that serve as regulatory interfaces to facilitate transmission of signals and to integrate synthesis of metabolic pathways such as lipids required for upholding cellular homeostasis in response to environmental and developmental inputs. Endoplasmic reticulum (ER) is the most copious endomembrane system that extend throughout the cell, and functions in production, processing, and transport of proteins and lipids, as well as in intracellular signaling. Reminiscent of the ancient Silk Road, ER connection to other membranous organelles via MCSs alters cellular landscape and serves as nexus for coordinating exchange of metabolites such as lipids, ions such as Ca2+, a...Continue Reading

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Citations

Jul 12, 2019·Cell Biology International·Guangang GaoLi Xu
Aug 2, 2019·The Plant Journal : for Cell and Molecular Biology·Thamali KariyawasamJae-Hyeok Lee
Jun 30, 2019·Current Opinion in Plant Biology·Anna-Lena Falz, Stefanie J Müller-Schüssele
Dec 29, 2020·Journal of Experimental Botany·Elina WelchenDaniel H Gonzalez
Mar 9, 2021·Frontiers in Cell and Developmental Biology·Bailey HewlettThierry Galli
Jun 3, 2021·Journal of Experimental Botany·Matteo Pivato, Matteo Ballottari
Nov 15, 2021·The FEBS Journal·Anna BoccaccioJoachim Scholz-Starke
Nov 23, 2021·Journal of Tissue Engineering and Regenerative Medicine·Mohammad Hossein KhosropanahMasoumeh Majidi Zolbin

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