PMID: 9536937Apr 16, 1998Paper

Eradicating Helicobacter pylori reduces hypergastrinaemia during long-term omeprazole treatment

Gut
A el-NujumiK E McColl

Abstract

Both proton pump inhibitor drug treatment and Helicobacter pylori infection cause hypergastrinaemia in man. To determine whether eradicating H pylori is a means of reducing hypergastrinaemia during subsequent proton pump inhibitor treatment. Patients with H pylori were randomised to treatment with either anti-H pylori or symptomatic treatment. One month later, all received four weeks treatment with omeprazole 40 mg/day for one month followed by 20 mg/day for six months. Serum gastrin concentrations were measured before and following each treatment. In the patients randomised to anti-H pylori treatment, eradication of the infection lowered median fasting gastrin by 48% and meal stimulated gastrin by 46%. When gastrin concentrations one month following anti-H pylori/symptomatic treatment were used as baseline, omeprazole treatment produced a similar percentage increase in serum gastrin in the H pylori infected and H pylori eradicated patients. Consequently, in the patients in which H pylori was not eradicated, median fasting gastrin concentration was 38 ng/l (range 26-86) at initial presentation and increased to 64 ng/l (range 29-271) after seven months omeprazole, representing a median increase of 68% (p < 0.005). In contrast, i...Continue Reading

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Citations

Jan 29, 2002·Lancet·Houman AshrafianRaymond J Playford
Apr 2, 1999·Alimentary Pharmacology & Therapeutics·S SanduleanuR W Stockbrügger
Oct 31, 2001·Alimentary Pharmacology & Therapeutics·D WilliamsJ Feely
Apr 28, 2007·Journal of Gastroenterology·Hiroshi HashimotoKazuyoshi Hirota
Jul 11, 2001·Scandinavian Journal of Gastroenterology·H J O'Connor, C A O'Morain
Feb 5, 2002·Expert Opinion on Pharmacotherapy·D A Gremse
Jul 26, 2011·Homeopathy : the Journal of the Faculty of Homeopathy·Marcus Zulian Teixeira
Jun 14, 2001·Best Practice & Research. Clinical Gastroenterology·D Gillen, K E McColl
Dec 21, 2018·International Journal of Molecular Sciences·Helge L Waldum, Reidar Fossmark

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