Eradication Efficacy of Modified Dual Therapy Compared with Bismuth-Containing Quadruple Therapy as a First-Line Treatment of Helicobacter pylori

The American Journal of Gastroenterology
Jing YangChun-Hui Lan

Abstract

This study assessed the effectiveness, adverse events, patient adherence, and costs of modified dual therapy compared with bismuth-containing quadruple therapy for treating Helicobacter pylori infection in Chinese patients. We also sought to determine whether modified dual therapy could be used as an alternative first-line treatment for H. pylori infection. A total of 232 H. pylori-infected, treatment-naive patients were enrolled in this open-label, randomized controlled clinical trial. Patients were randomly allocated into 2 groups: the 14-day modified dual therapy group and the bismuth-containing quadruple therapy group. Eradication rates, drug-related adverse events, patient compliance, and drug costs were compared between the 2 groups. The modified dual therapy group achieved eradication rates of 87.9%, 91.1%, and 91.1% as determined by the intention-to-treat, per-protocol, and modified intention-to-treat analyses, respectively. The eradication rates were similar compared with the bismuth-containing quadruple therapy group: 89.7%, 91.2%, and 90.4%. In addition, modified dual therapy ameliorated variations in the CYP2C19, IL-1B-511, and H. pylori VacA genotypes. There were no significant differences in the compliance rates b...Continue Reading

References

Mar 1, 1996·Helicobacter·R W van der HulstG N Tytgat
Jun 14, 2001·Best Practice & Research. Clinical Gastroenterology·J Labenz
Oct 8, 2004·Clinical Pharmacology and Therapeutics·Mitsushige SugimotoTakashi Ishizaki
Jan 12, 2007·Clinical Pharmacology and Therapeutics·T FurutaA Hishida
Aug 3, 2007·Helicobacter·David Y GrahamYoshio Yamaoka
Oct 19, 2010·Gastroenterology Clinics of North America·Takahisa Furuta, David Y Graham
Jun 22, 2011·British Journal of Clinical Pharmacology·Seung Young KimJai Hyun Choi
May 8, 2014·World Journal of Gastroenterology : WJG·Xi-Qing JiBo Yu
Dec 3, 2014·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Jyh-Chin YangJau-Min Wong
Mar 7, 2015·Drugs·Karly P Garnock-Jones
Jul 19, 2015·Gut·Kentaro SuganoUNKNOWN faculty members of Kyoto Global Consensus Conference
Apr 15, 2016·Expert Review of Anti-infective Therapy·David Y Graham, Maria Pina Dore
Jul 15, 2016·Gastroenterology Research and Practice·WonGun KwackDavid Y Graham
Jul 30, 2016·The Lancet Global Health·Martyn PlummerSilvia Franceschi
Nov 2, 2016·Gut·P MalfertheinerUNKNOWN European Helicobacter and Microbiota Study Group and Consensus panel
May 4, 2017·Nature Reviews. Gastroenterology & Hepatology·Bich N Dang, David Y Graham
Aug 7, 2017·The Lancet. Gastroenterology & Hepatology·Yu-Ting KuoUNKNOWN Asian Pacific Alliance on Helicobacter and Microbiota
Sep 25, 2017·Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association·Jia-Li HuDian-Chun Fang

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Citations

Aug 23, 2019·Current Opinion in Gastroenterology·Erick A Argueta, Steven F Moss
Jan 14, 2020·Chinese Medical Journal·Yi HuNong-Hua Lu
Sep 23, 2020·Expert Review of Gastroenterology & Hepatology·Jianwei YunDekui Zhang
Sep 15, 2020·World Journal of Gastroenterology : WJG·Tian-Lian YanCheng-Fu Xu
Sep 2, 2020·Current Opinion in Gastroenterology·Erick A Argueta, Steven F Moss
Nov 3, 2020·Expert Opinion on Pharmacotherapy·Sotirios Georgopoulos, Vasilios Papastergiou
Jun 3, 2021·Antibiotics·Vincenzo De FrancescoDino Vaira
Jul 16, 2021·Therapeutic Advances in Gastroenterology·Caiqi LiuTongsen Zheng

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