Eradication of common pathogens at days 2, 3 and 4 of moxifloxacin therapy in patients with acute bacterial sinusitis.

BMC Ear, Nose, and Throat Disorders
Horacio ArizaPeter Pertel

Abstract

Acute bacterial sinusitis (ABS) is a common infection in clinical practice. Data on time to bacteriologic eradication after antimicrobial therapy are lacking for most agents, but are necessary in order to optimize therapy. This was a prospective, single-arm, open-label, multicenter study to determine the time to bacteriologic eradication in ABS patients (maxillary sinusitis) treated with moxifloxacin. Adult patients with radiologically and clinically confirmed ABS received once-daily moxifloxacin 400 mg for 10 days. Middle meatus secretion sampling was performed using nasal endoscopy pre-therapy, and repeated on 3 consecutive days during treatment. Target enrollment was 30 bacteriologically evaluable patients (pre-therapy culture positive for Streptococcus pneumoniae, Haemophilus influenzae or Moraxella catarrhalis and evaluable cultures for at least Day 2 and Day 3 during therapy visits), including at least 10 each with S. pneumoniae or H. influenzae. Of 192 patients enrolled, 42 were bacteriologically evaluable, with 48 pathogens isolated. Moxifloxacin was started on Day 1. Baseline bacteria were eradicated in 35/42 (83.3%) patients by day 2, 42/42 (100%) patients by day 3, and 41/42 (97.6%) patients by day 4. In terms of ind...Continue Reading

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Citations

Sep 3, 2008·The Journal of Laryngology and Otology·T Galm, N Turner
Jan 14, 2010·The Journal of Laryngology and Otology·M MohammadiA Basam
Apr 28, 2010·The Laryngoscope·James A HadleyZeljka Herman-Gnjidic
Aug 1, 2008·Expert Review of Respiratory Medicine·Hartmut M Lode, Malina Schmidt-Ioanas
Aug 18, 2009·Expert Review of Anti-infective Therapy·Olaf Burkhardt, Tobias Welte
Sep 4, 2015·Vestnik otorinolaringologii·A Y OvchinnikovS A Korostelev

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Methods Mentioned

BETA
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SAS

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