PMID: 6974221Sep 1, 1981Paper

Eradication of disseminated murine leukemia by chemoimmunotherapy with cyclophosphamide and adoptively transferred immune syngeneic Lyt-1+2- lymphocytes

The Journal of Experimental Medicine
P D GreenbergA Fefer

Abstract

The phenotype of T cells therapeutically effective in immunotherapy of advanced Friend virus-induced (FBL) leukemia in vivo and cytotoxic to FBL in vitro was determined. Mice bearing disseminated FBL leukemia were successfully treated by a combination of cyclophosphamide and adoptive transfer of syngeneic immune lymphocytes. Therapeutic efficacy was largely dependent on the presence of Lyt-1+2- T cells in the transferred cells, whereas cells cytotoxic to FBL tumor in vitro were derived from the Lyt-1+2+ and Lyt-1-2+ subsets. Thus, the predominate cell required to eradicate tumor in adoptive chemoimmunotherapy was not cytolytic to tumor in vitro. Potentially, the Lyt-1+2- cell may operate in vivo as an amplifier cell rather than by a direct anti-tumor effect. Elimination of the Lyt-1+ population with alpha-Lyt-1 and complement prevented the generation of significant cytotoxic responses during both primary in vitro sensitization to alloantigens and in vitro sensitization of tumour-primed cells. The capacity of Lyt-1+ cell-depleted population to generate cytotoxic responses was partially reconstituted by addition, at the initiation of culture, of interluekin 2, a T cell growth factor derived from Lyt-1+2- cells, which contain the ...Continue Reading

References

Oct 1, 1976·The Journal of Experimental Medicine·H ShikuH F Oettgen
Apr 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·E NakayamaL J Old
Jun 1, 1979·The Journal of Experimental Medicine·S GillisK A Smith
Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·O StutmanE A Boyse
Jan 11, 1976·Annals of the New York Academy of Sciences·A FeferJ R Berenson
Jan 1, 1980·Immunological Reviews·H R MacDonaldK T Brunner
Oct 1, 1980·The Journal of Experimental Medicine·E Fernandez-CruzJ D Feldman

❮ Previous
Next ❯

Citations

Jan 1, 1986·Cancer Metastasis Reviews·T Tachibana, K Yoshida
Jan 1, 1993·Cancer Immunology, Immunotherapy : CII·F CuloT Kolak
Jan 1, 1985·Springer Seminars in Immunopathology·F SpreaficoA Montovani
Jun 21, 2005·Springer Seminars in Immunopathology·Mara Gerloni, Maurizio Zanetti
Sep 1, 1990·Veterinary Immunology and Immunopathology·K L O'ReillyG A Splitter
Oct 1, 1996·Current Opinion in Immunology·E M Jaffee, D M Pardoll
Jul 6, 2002·Critical Reviews in Oncology/hematology·Rong-Fu WangHan Ying
Dec 8, 2007·Nature Medicine·Drew M Pardoll
Mar 23, 2012·Nature Reviews. Immunology·Nicholas P RestifoSteven A Rosenberg
Sep 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·M O DaileyI L Weissman
Mar 2, 1999·The Journal of Experimental Medicine·R E ToesC J Melief
Oct 6, 2010·The Journal of Experimental Medicine·Andrea SchietingerHans Schreiber
Nov 24, 1999·Immunological Reviews·R F Wang, S A Rosenberg
Oct 31, 1996·Annals of the New York Academy of Sciences·H FujiwaraT Hamaoka
Jun 1, 2012·Clinical & Developmental Immunology·Ivetta DanyleskoArnon Nagler
Mar 9, 2012·Clinical & Developmental Immunology·Zhi-Chun Ding, Gang Zhou
Sep 19, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Chrystal M PaulosNicholas P Restifo
Apr 17, 2003·The Journal of Clinical Investigation·Claudia CurcioGuido Forni
May 29, 1998·The Journal of Clinical Investigation·P YotndaP Langlade-Demoyen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.