Eradication of hepatitis C virus is associated with the attenuation of steatosis as evaluated using a controlled attenuation parameter

Scientific Reports
Kohei ShimizuHitoshi Ikeda

Abstract

Chronic hepatitis C virus (HCV) infection was shown to cause hepatic steatosis or suppression of serum lipid levels. However, little is known about the changes in hepatic steatosis following HCV eradication. We aimed to evaluate this issue using the controlled attenuation parameter (CAP), which was recently shown to provide a standardized non-invasive measure of hepatic steatosis. We enrolled 70 patients with chronic HCV infections and steatosis (CAP of over 248 dB/m) who had achieved a sustained viral response at 12 weeks after discontinuation of antiviral treatment using direct-acting antivirals (DAA). We then evaluated the state of hepatic steatosis before and after HCV eradication. We also investigated the changes in serum parameters such as cholesterol and glucose levels. The median value of CAP level decreased significantly after HCV eradication from 273 dB/m to 265 dB/m (P = 0.034). Also, LDL and HDL cholesterol levels increased significantly after HCV eradication (P = 0.002 and P = 0.027, respectively). In conclusion, a decrease in hepatic steatosis after HCV eradication with DAA was revealed in chronic hepatitis C patients with significant steatosis. Cancellation of the viral effect is a possible underlying cause of he...Continue Reading

References

Apr 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·N BachF Schaffner
Jan 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·E E PowellL W Powell
Feb 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·G BarbaC Bréchot
Jul 1, 1997·The Journal of General Virology·K MoriyaK Koike
Feb 18, 1999·Journal of Medical Virology·M MonazahianR Thomssen
Sep 25, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A SabileG Barba
Oct 27, 1999·Proceedings of the National Academy of Sciences of the United States of America·V AgnelloQ X Zhang
Jun 8, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·L E AdinolfiG Ruggiero
Jan 31, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Gabriel PerlemuterChristian Bréchot
Apr 18, 2003·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Kyoji MoriyaKazuhiko Koike
Sep 23, 2003·The American Journal of Gastroenterology·Arun J SanyalA Scott Mills
Oct 28, 2004·Gastroenterology·Giovanna FattovichFrancesco Donato
May 18, 2006·The Journal of Biological Chemistry·Steeve BoulantJohn McLauchlan
Feb 24, 2009·Liver International : Official Journal of the International Association for the Study of the Liver·Francesco Negro, Arun J Sanyal
Sep 30, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Kathleen E CoreyRaymond T Chung
Jul 17, 2010·Oncology·Kazuhiko KoikeKyoji Moriya
Jun 10, 2011·Expert Review of Gastroenterology & Hepatology·Hervé LeratJean-Michel Pawlotsky
Nov 17, 2014·Digestive Diseases and Sciences·Grace Lai-Hung Wong, Vincent Wai-Sun Wong
Nov 4, 2016·Liver International : Official Journal of the International Association for the Study of the Liver·Jacqueline A BachofnerJoachim C Mertens
Apr 22, 2017·World Journal of Gastroenterology : WJG·Daisuke EndoYoshio Aizawa

❮ Previous
Next ❯

Citations

May 3, 2019·Haemophilia : the Official Journal of the World Federation of Hemophilia·Azusa NagaoTakashi Suzuki
Nov 21, 2020·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Annalisa CespiatiAnna Ludovica Fracanzani
Jan 6, 2021·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Pei-Yuan SuYu-Chun Hsu
Mar 13, 2021·International Journal of Clinical Practice·Anahita SadeghiShahin Merat
Jun 18, 2021·Frontiers in Medicine·Sergio EstefanMarcia Helena S Costa
Aug 31, 2021·Liver International : Official Journal of the International Association for the Study of the Liver·Takuma NakatsukaKazuhiko Koike

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy

Software Mentioned

FibroScan
SPSS

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.