Eradication rate of Helicobacter pylori reinfection in Korea: A retrospective study

Journal of Gastroenterology and Hepatology
Young Kwon ChoiHwoon-Yong Jung

Abstract

Guidelines for selecting the eradication regimen for Helicobacter pylori reinfection remain unclear. This study aimed to evaluate the eradication rate of H. pylori reinfection in patients with a previous infection successfully eradicated with index triple therapy. This was a single-center, retrospective case-control study. A total of 10 468 H. pylori-infected patients treated with proton-pump inhibitor-based triple eradication therapy at a tertiary medical institution between 2005 and 2016 were enrolled. We reviewed the medical records of the enrolled patients and compared the treatment outcomes in those with H. pylori reinfection after a successful eradication. Helicobacter pylori infection was successfully eradicated with the index triple therapy in 7770 patients (74.2%). Among 3567 patients followed up for > 1 year, H. pylori reinfection occurred in 420 (11.8%; 3.06% per person-year) during a median follow-up of 39.1 months (interquartile range, 23.5-58.7 months). Of these patients, 164 received eradication therapy for reinfection (triple therapy in 102 and quadruple therapy in 62) and had follow-up data. Triple therapy showed an eradication rate of 78.4% for H. pylori reinfection, which was not significantly different from ...Continue Reading

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Citations

Sep 13, 2020·Helicobacter·Linda MezmaleMarcis Leja
Sep 6, 2019·Helicobacter·Anthony O'ConnorColm O'Morain
Nov 3, 2020·Gastroenterology Research and Practice·Zhi-Ning YeXing-Xiang He
Dec 24, 2021·The Journal of International Medical Research·Guang ZhaoSu'nan Wang

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