Eradication Rate ofHelicobacter pylori on the US-Mexico Border Using the Urea Breath Test

Southern Medical Journal
Roy P LiuMarc J Zuckerman

Abstract

Helicobacter pylori is prevalent worldwide, especially in Latin America. Triple and quadruple antibiotic therapies have been relatively effective; however, resistance has emerged in recent years. The treatment success rate of these regimens on the border of the United States and Mexico is unknown. Our study attempted to determine eradication rates of two major regimens based on urea breath test (UBT) results in patients previously diagnosed as havingH. pyloriin a single center in El Paso, Texas, a city on the geographic border with Mexico. This was a retrospective cohort study of adult patients withH. pyloriwho underwent UBT after being treated with triple therapy (amoxicillin/clarithromycin/proton pump inhibitor for 14 days), quadruple therapy (tetracycline/metronidazole/bismuth/proton pump inhibitor, usually for 10 days), or both forH. pylorifrom 2010 to 2015 in a county hospital. Patients were excluded if they did not complete therapy or if their treatment regimen was unknown. The Studentttest and the χ2test were used to analyze the data. The cumulative incidence and 95% confidence interval (CI) for treatment success were estimated. A total of 104 patients completed the treatment forH. pyloriand had UBT. Mean age was 53 year...Continue Reading

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