Eradication Therapy against Pseudomonas aeruginosa in Non-Cystic Fibrosis Bronchiectasis

Respiration; International Review of Thoracic Diseases
Ramon OrriolsBruno Montoro

Abstract

No prospective study has assessed eradication treatment of early Pseudomonas aeruginosa colonisation in bronchiectasis not due to cystic fibrosis (CF). To evaluate the efficacy of 3 months of nebulised tobramycin after a short course of intravenous antibiotics in the eradication of P. aeruginosa and its clinical consequences in non- CF bronchiectasis following initial P. aeruginosa infection. A 15-month, single-masked, randomised study including 35 patients was conducted in a tertiary university hospital. Following the isolation of P. aeruginosa and a 14-day intravenous treatment with ceftazidime and tobramycin, patients received 300 mg nebulised tobramycin twice daily or placebo during 3 months, and were followed up for 12 months thereafter. The median time to recurrence of P. aeruginosa infection was higher in the tobramycin than in the placebo group (p = 0.048, log-rank test). At the end of the study 54.5% of the patients were free of P. aeruginosa in the tobramycin group and 29.4% in the placebo group. The numbers of exacerbations (p = 0.044), hospital admissions (p = 0.037) and days of hospitalisation (p = 0.034) were lower in the tobramycin than in the placebo group. A global, non-significant trend to improvement in the t...Continue Reading

Associated Clinical Trials

Citations

Jun 12, 2018·The Cochrane Database of Systematic Reviews·Lambert M FelixSally Spencer
Sep 13, 2018·Respirology : Official Journal of the Asian Pacific Society of Respirology·Scott C BellCatherine A Byrnes
Dec 14, 2018·Thorax·Adam T HillMichael R Loebinger
Jun 12, 2016·The European Respiratory Journal·Stefano AlibertiUNKNOWN EMBARC Study Group
Apr 14, 2017·The European Respiratory Journal·Emilie VallièresDamian G Downey
Mar 16, 2019·European Respiratory Review : an Official Journal of the European Respiratory Society·Megan L CrichtonJames D Chalmers
Jan 13, 2019·The European Respiratory Journal·Angelina PietersMenno M van der Eerden
Aug 14, 2019·Expert Review of Respiratory Medicine·Johnny WuDanielle F Wurzel
Aug 14, 2015·The Cochrane Database of Systematic Reviews·Khin HninBrian J Smith
Dec 23, 2017·Expert Review of Clinical Pharmacology·Andrea S MelaniPaola Rottoli
Dec 6, 2019·Breathe·Diego Severiche-BuenoSanjay H Chotirmall
Dec 26, 2019·Current Pulmonology Reports·R Somayaji, C H Goss
Jan 18, 2018·Expert Opinion on Investigational Drugs·Sabina Antonela Antoniu
Nov 18, 2019·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Leire LeacheAna Ortega
Jul 4, 2020·Therapeutic Advances in Respiratory Disease·Meng-Jiao Xu, Bing Dai
Sep 5, 2019·Chronic Respiratory Disease·Marina Blanco-AparicioCarmen Montero Martínez
Sep 26, 2020·Pneumologie·J RaidtH Omran
Dec 2, 2020·Journal of Clinical Medicine·Marta Garcia-ClementeMiguel Angel Martinez-García
Dec 23, 2020·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Elif TanriverdiErdoğan Cetinkaya
Jul 16, 2019·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·Y-H Chai, J-F Xu
Mar 20, 2021·Expert Review of Respiratory Medicine·Celine Vidaillac, Sanjay H Chotirmall
Sep 26, 2020·The Korean Journal of Internal Medicine·Ho Cheol KimSei Won Lee
Jul 15, 2021·Seminars in Respiratory and Critical Care Medicine·Laia Fernández-BaratAntoni Torres
Jul 15, 2021·Seminars in Respiratory and Critical Care Medicine·Stephanie DetailleurPieter Goeminne

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.