Erase-Maintain-Establish: Natural Reprogramming of the Mammalian Epigenome

Cold Spring Harbor Symposia on Quantitative Biology
Milena LesevaDavor Solter

Abstract

The genetic information is largely identical across most cell types in a given organism but the epigenome, which controls expression of the genome, is cell type- and context-dependent. Although most mature mammalian cells appear to have a stable, heritable epigenome, a dynamic intricate process reshapes it as these cells transition from soma to germline and back again. During normal embryogenesis, primordial germ cells, of somatic origin, are set aside to become gametes. In doing so their genome is reprogrammed-that is, the epigenome of specific regions is replaced in a sex-specific fashion as they terminally differentiate into oocytes or spermatocytes in the gonads. Upon union of these gametes, reprogramming of the new organism's epigenome is initiated, which eventually leads, through pluripotent cells, to the cell lineages required for proper embryonic development to a sexually mature adult. This never-ending cycle of birth and rebirth is accomplished through methylation and demethylation of specific genomic sites within the gametes and pluripotent cells of an organism. This enigmatic process of natural epigenomic reprogramming is now being dissected in vivo, focusing on specific genomic regions-that is, imprinted genes and r...Continue Reading

References

Mar 10, 2001·Nature·E S LanderUNKNOWN International Human Genome Sequencing Consortium
Dec 6, 2002·Nature·UNKNOWN Mouse Genome Sequencing ConsortiumEric S Lander
Jan 21, 2003·Biology of Reproduction·Daisuke KigamiHiroshi Imai
Jun 4, 2004·Reproduction : the Official Journal of the Society for the Study of Fertility·Fátima Santos, Wendy Dean
Aug 12, 2004·FEBS Letters·Akiko SatouHiroyoshi Ariga
Aug 20, 2004·Nature·Déborah Bourc'his, Timothy H Bestor
Oct 8, 2004·Developmental Cell·Anne E PeastonBarbara B Knowles
Aug 19, 2005·The EMBO Journal·Chuangui WangJiandong Chen
Oct 13, 2006·Bioinformatics·Zoë Birtle, Chris P Ponting
Aug 21, 2007·The Journal of Biological Chemistry·Chuangui WangJiandong Chen
Sep 26, 2007·The Journal of Biological Chemistry·Maciej WiznerowiczDidier Trono
Apr 3, 2008·Biochemical and Biophysical Research Communications·Shinya KamitaniTadashi Matsuda
Oct 16, 2008·Developmental Cell·Xiajun LiAnne C Ferguson-Smith
Mar 10, 2009·Nature·Daniel Wolf, Stephen P Goff
Oct 23, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kyoko TakahashiShuichi Kaminogawa
Oct 24, 2009·The Journal of Biological Chemistry·Hongzhuang PengFrank J Rauscher
Jan 16, 2010·Nature·Helen M RoweDidier Trono
May 29, 2010·Proceedings of the National Academy of Sciences of the United States of America·Yasuhiro SekiMakoto Asashima
Nov 9, 2010·Nature Genetics·Julie BorgelMichael Weber
Feb 16, 2011·Proceedings of the National Academy of Sciences of the United States of America·Khursheed IqbalPiroska E Szabó
Mar 17, 2011·Nature Communications·Mark WossidloJörn Walter
Jun 10, 2011·The Journal of Biological Chemistry·Sushma Iyengar, Peggy J Farnham
Jul 26, 2011·Genome Research·James H Thomas, Sean Schneider
Aug 4, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shinya KamitaniTadashi Matsuda
Sep 24, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Qiming LiangFanxiu Zhu

❮ Previous
Next ❯

Citations

Jun 10, 2016·Critical Reviews in Toxicology·Emma L MarczyloTimothy W Gant
Feb 12, 2019·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Colleen Jackson-Cook
Feb 6, 2019·Chromosoma·Prim B SinghStepan N Belyakin
Aug 17, 2020·Cells·Prim B SinghPetr P Laktionov
Sep 15, 2020·The Journal of Biological Chemistry·Rebecca R Florke GeePatrick Ryan Potts
Aug 1, 2020·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Rossella TricaricoErica A Golemis

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Current Opinion in Cell Biology
Davood Sabour, Hans R Schöler
Doklady Biological Sciences : Proceedings of the Academy of Sciences of the USSR, Biological Sciences Sections
Olga F GordeevaN G Khrushchov
Current Opinion in Genetics & Development
Peter J Donovan, Maria P de Miguel
© 2022 Meta ULC. All rights reserved