Erasure of histone acetylation by Arabidopsis HDA6 mediates large-scale gene silencing in nucleolar dominance.

Genes & Development
Keith EarleyCraig S Pikaard

Abstract

Nucleolar dominance describes the silencing of one parental set of ribosomal RNA (rRNA) genes in a genetic hybrid, an epigenetic phenomenon that occurs on a scale second only to X-chromosome inactivation in mammals. An RNA interference (RNAi) knockdown screen revealed that the predicted Arabidopsis histone deacetylase, HDA6, is required for rRNA gene silencing in nucleolar dominance. In vivo, derepression of silenced rRNA genes upon knockdown of HDA6 is accompanied by nucleolus organizer region (NOR) decondensation, loss of promoter cytosine methylation, and replacement of histone H3 Lys 9 (H3K9) dimethylation with H3K4 trimethylation, H3K9 acetylation, H3K14 acetylation, and histone H4 tetra-acetylation. Consistent with these in vivo results, purified HDA6 deacetylates lysines modified by histone acetyltransferases whose substrates include H3K14, H4K5, and H4K12. HDA6 localizes, in part, to the nucleolus, supporting a model whereby HDA6 erases histone acetylation as a key step in an epigenetic switch mechanism that silences rRNA genes through concerted histone and DNA modifications.

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Citations

Feb 15, 2013·Plant Cell Reports·Xujun MaChuanping Yang
Oct 18, 2008·Chromosoma·Peter C McKeown, Peter J Shaw
Oct 6, 2009·Functional & Integrative Genomics·Sadegh Azimzadeh Jamalkandi, Ali Masoudi-Nejad
Sep 2, 2011·Plant Molecular Biology·Ryo FujimotoElizabeth S Dennis
Jan 3, 2007·Nature Cell Biology·Craig Pikaard, Olga Pontes
Jun 27, 2012·Proceedings of the National Academy of Sciences of the United States of America·Xiaojie LiZhizhong Gong
Jun 4, 2010·Journal of Experimental Botany·Li-Ting ChenKeqiang Wu
Sep 20, 2011·Journal of Experimental Botany·Jian-fei KuangWang-jin Lu
Mar 1, 2012·Journal of Experimental Botany·Ming LuoKeqiang Wu
Dec 17, 2011·Plant & Cell Physiology·Elodie LayatSylvette Tourmente
May 3, 2012·Genes & Development·Frédéric PontvianneCraig S Pikaard
Jul 24, 2013·Plant Physiology·Riccardo Aiese CiglianoClara Conicella
Jul 12, 2008·Annual Review of Cell and Developmental Biology·Brian McStay, Ingrid Grummt
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Jun 1, 2012·Genetics·Frauke Greil, Kami Ahmad
Sep 4, 2012·International Journal of Molecular Sciences·Kenji OsabeRyo Fujimoto

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