PMID: 11926320Apr 3, 2002Paper

ErbB-4: a receptor tyrosine kinase

Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]
W Zhou, G Carpenter

Abstract

ErbB-4 is a receptor tyrosine kinase that is activated by the binding of specific growth factors to its ectodomain. In addition to the initiation of signal transduction pathways that direct cell responses, such as proliferation or differentiation, this receptor is subject to ligand-dependent trafficking events. The signal transduction events are controlled by ligand-dependent activation of the receptor tyrosine kinase activity, which results in receptor autophosphorylation and the tyrosine phosphorylation of other cellular proteins. The trafficking events include migration into and out of membrane microdomains, entry into internalization pathways and endocytosis, plus proteolytic fragmentation.

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Dec 8, 2011·Bulletin of Mathematical Biology·Max R BennettWilliam G Gibson
Mar 22, 2003·Experimental Cell Research·Graham Carpenter
Mar 22, 2003·Current Opinion in Cell Biology·Graham Carpenter
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Cell Signaling by Tyrosine Kinases

Receptor tyrosine kinases (RTKs) are the high-affinity cell surface receptors for many polypeptide growth factors, cytokines, and hormones. RTKs have been shown not only to be key regulators of normal cellular processes but also to have a critical role in the development and progression of many types of cancer. Discover the latest research on cell signaling and RTK here.

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