ErbB3/HER3 does not homodimerize upon neuregulin binding at the cell surface

FEBS Letters
Mitchell B BergerM A Lemmon

Abstract

To understand signaling by the neuregulin (NRG) receptor ErbB3/HER3, it is important to know whether ErbB3 forms homodimers upon ligand binding. Previous biophysical studies suggest that the ErbB3 extracellular region remains monomeric when bound to NRG. We used a chimeric receptor approach to address this question in living cells, fusing the extracellular region of ErbB3 to the kinase-active intracellular domain of ErbB1. The ErbB3/ErbB1 chimera responded to NRG only if ErbB2 was co-expressed in the same cells, whereas an ErbB4/ErbB1 chimera responded without ErbB2. We, therefore, suggest that ErbB3 is an obligate heterodimerization partner because of its inability to homodimerize.

References

Jul 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·G D PlowmanM Shoyab
Dec 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·M H KrausS A Aaronson
Oct 13, 1995·The Journal of Biological Chemistry·T HoranJ S Philo
Aug 16, 1994·Proceedings of the National Academy of Sciences of the United States of America·P M GuyK L Carraway
Aug 9, 1996·The Journal of Biological Chemistry·R Pinkas-KramarskiY Yarden
May 2, 1997·The Journal of Biological Chemistry·D C GamettI Friedberg
Aug 15, 1997·The EMBO Journal·E TzaharY Yarden
Jul 29, 2000·Biochemistry·R Landgraf, D Eisenberg
Sep 6, 2000·The EMBO Journal·K M FergusonM A Lemmon
Nov 1, 2000·Cell·J Schlessinger
Mar 17, 2001·Nature Reviews. Molecular Cell Biology·Y Yarden, M X Sliwkowski
Aug 3, 2002·Science·Hyun-Soo Cho, Daniel J Leahy
Mar 22, 2003·Experimental Cell Research·Ami CitriYosef Yarden
Mar 22, 2003·Experimental Cell Research·Graham Carpenter
Mar 22, 2003·Experimental Cell Research·Thomas HolbroNancy E Hynes
Jul 11, 2003·Proceedings of the National Academy of Sciences of the United States of America·Thomas HolbroNancy E Hynes
Oct 7, 2003·Molecular Cell·Antony W BurgessShigeyuki Yokoyama

❮ Previous
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Citations

Mar 11, 2008·Cellular and Molecular Life Sciences : CMLS·J Laliberté, V B Carruthers
Apr 12, 2008·Cancer Gene Therapy·G Sithanandam, L M Anderson
Jun 19, 2009·Nature Reviews. Cancer·José Baselga, Sandra M Swain
Dec 17, 2009·Proceedings of the National Academy of Sciences of the United States of America·Natalia JuraJohn Kuriyan
Aug 15, 2012·Proceedings of the National Academy of Sciences of the United States of America·Michio HiroshimaYasushi Sako
May 31, 2011·The Journal of Biological Chemistry·Steven M JayLinda G Griffith
Mar 23, 2012·Carcinogenesis·Malgorzata Magdalena SakInger Helene Madshus
Jan 15, 2009·Journal of the National Cancer Institute·Tracy E StreckerPowel H Brown
Aug 5, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Erez M BublilYosef Yarden
Oct 23, 2010·Current Opinion in Obstetrics & Gynecology·Hiroshi TsujiokaShingo Miyamoto
Jul 19, 2012·Biochemistry. Biokhimii︠a︡·O L PolanovskiS M Deyev
Jun 8, 2006·Annual Review of Biochemistry·Dario R AlessiJose R Bayascas
Dec 1, 2012·Chemotherapy Research and Practice·Ning JiangZhuo Georgia Chen
Nov 1, 2011·Cell Communication and Signaling : CCS·Jens RauchWalter Kolch
Jul 8, 2010·Breast Cancer Research : BCR·Leonard Da SilvaSunil R Lakhani
Jan 23, 2014·Acta Biochimica Et Biophysica Sinica·Youngseok LeeBolin Liu
Oct 6, 2005·Proceedings of the National Academy of Sciences of the United States of America·Samuel BouyainDaniel J Leahy
Jan 31, 2014·Cardiovascular Research·Emily M Parodi, Bernhard Kuhn
Dec 7, 2006·Proceedings of the National Academy of Sciences of the United States of America·T S WehrmanH M Blau
May 14, 2014·Trends in Cell Biology·Veronika ReitererHesso Farhan
Mar 31, 2010·Proceedings of the National Academy of Sciences of the United States of America·Fumin ShiMark A Lemmon
Aug 27, 2015·Expert Opinion on Drug Metabolism & Toxicology·Andrea RoccaDino Amadori
Apr 24, 2012·Current Opinion in Structural Biology·Colin W Ward, Michael C Lawrence
Oct 19, 2010·Critical Reviews in Oncology/hematology·Anna EmdeUNKNOWN Association of Radiotherapy and Oncology of the Mediterranean arEa (AROME)
Sep 8, 2010·Seminars in Cell & Developmental Biology·Dhara N AminMark M Moasser
Jun 12, 2010·Journal of Dermatological Science·Sofi Forsberg, Ola Rollman
Oct 27, 2015·Acta Biochimica Et Biophysica Sinica·Ningyan ZhangZhiqiang An
Feb 12, 2009·Current Opinion in Cell Biology·Nancy E Hynes, Gwen MacDonald
Nov 29, 2008·Experimental Cell Research·Mark A Lemmon
Nov 11, 2008·Experimental Cell Research·Karl R Schmitz, Kathryn M Ferguson
Sep 9, 2010·International Journal of Cancer. Journal International Du Cancer·Alexandre Ho-Pun-CheungEvelyne Lopez-Crapez
Jun 3, 2014·Molecular Cancer·Jian MaBolin Liu
Aug 2, 2006·Trends in Cell Biology·Jérôme BoudeauDario R Alessi
Jul 19, 2013·Biochemical Society Transactions·Jeannine M MendrolaMark A Lemmon
Oct 21, 2010·Biochimica Et Biophysica Acta·Nadezhda N ZheleznovaAlexander Staruschenko

❮ Previous
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