ERCC1 mRNA levels complement thymidylate synthase mRNA levels in predicting response and survival for gastric cancer patients receiving combination cisplatin and fluorouracil chemotherapy

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
R MetzgerL Leichman

Abstract

We have previously shown that relative thymidylate synthase (TS) mRNA levels in primary gastric adenocarcinomas treated with fluorouracil (5-FU) and cisplatin are inversely associated with response and survival. This is a presumed function of TS as a target for 5-FU activity. We now test the hypotheses that the relative mRNA level of the excision repair cross-complementing (ERCC1) gene is inversely associated with response and survival as an independent function of cisplatin efficacy. Patients had intact, untreated, primary gastric adenocarcinoma cancer and were evaluated for eligibility on a preoperative cisplatin infusion-5-FU protocol. cDNA, derived from primary gastric tumors before chemotherapy, was used to determine ERCC1 mRNA levels, expressed as the ratio of polymerase chain reaction (PCR) product of the ERCC1 gene and the beta-actin gene. The median ERCC1 mRNA level from 38 primary gastric cancers (33 assessable for response) was 5.8 x 10(-3) (range, 1.8 x 10(-3) to 19.5 x 10(-3)). Of 17 responding patients, 13 (76%) were less than or equal to 5.8 x 10(-3) and four were greater than 5.8 x 10(-3) (P = .003). The median survival for patients with ERCC1 mRNA levels less than or equal to 5.8 x 10(-3) has not been reached, ...Continue Reading

Citations

Jun 23, 2000·Drugs·G Giaccone
Aug 14, 2003·Cancer Control : Journal of the Moffitt Cancer Center·Rafael RosellBarbara Roig
Aug 19, 2004·International Journal of Cancer. Journal International Du Cancer·Wataru IchikawaRenzo Hirayama
Dec 27, 2005·Annals of Surgical Oncology·Steven R DeMeester
Apr 25, 2006·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Mariacarmela SantarpiaRafael Rosell
Sep 5, 2006·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Wataru Ichikawa
Nov 8, 2007·PloS One·Rafael RosellJacek Jassem
Nov 15, 2008·World Journal of Gastroenterology : WJG·Zhao-Hui HuangXi-Ke Zhou
Jul 25, 2009·International Journal of Cancer. Journal International Du Cancer·Hua-Yun ChenZhong-Ping Chen
Mar 12, 2011·Journal of Korean Medical Science·Dokyung KimJa Seung Koo
May 21, 2011·Annals of Thoracic and Cardiovascular Surgery : Official Journal of the Association of Thoracic and Cardiovascular Surgeons of Asia·Ekrem Cengiz SeyhanNeslihan Fener
Jan 18, 2012·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Dianke YuMing Yang
Jul 5, 2013·Nature Reviews. Cancer·Jason W Locasale
Dec 12, 2013·Journal of Gastrointestinal Cancer·Vanessa da Costa MirandaRachel P Riechelmann
Feb 11, 2014·International Journal of Cancer. Journal International Du Cancer·Gregory T Wurz, Michael W Degregorio
Jan 1, 2011·Cancers·Jean-Baptiste BachetJean-Luc Van Laethem
Apr 18, 2015·BMC Cancer·Jianwei WangBinghui Shen
Jan 21, 2016·Oncology Letters·Rina KatoIchio Fukasawa
Mar 1, 2019·Current Molecular Medicine·Jun ZhouWei Song
Oct 16, 2019·Cellular and Molecular Life Sciences : CMLS·Apostolos KlinakisTheodoros Rampias
Sep 11, 2019·PloS One·Manida SuksawatWatcharin Loilome
Dec 10, 2019·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Syma IqbalHoward S Hochster
Feb 27, 2001·Current Opinion in Oncology·R RosellA O'Brate
Apr 9, 2002·Current Oncology Reports·David H Ilson

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