ERCC2/XPD Lys751Gln and Asp312Asn gene polymorphism and lung cancer risk: a meta-analysis involving 22 case-control studies

Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer
Ping ZhanYong Song

Abstract

Published data on the association between XPD Lys751Gln and Asp312Asn gene polymorphism and lung cancer risk are inconclusive. To derive a more precise estimation of the relationship, a meta-analysis was performed. A total of 22 studies including 15,507 subjects for XPD Lys751Gln genotype and 13,198 subjects for XPD Asp312Asn genotype were examined. For XPD Lys751Gln genotype, significantly increased lung cancer risk was associated with two variant genotypes (CC versus AA: odds ratio [OR] = 1.26, 95% confidence interval [CI] = 1.12-1.42, p = 0.473 for heterogeneity; C allele carriers versus AA: OR = 1.18, 95% CI = 1.08-1.36, p = 0.732 for heterogeneity). When stratified by ethnicity, significantly increased risks were found among Caucasians but not in Asians. For XPD Asp312Asn genotype, significantly increased lung cancer risk was associated with two variant genotypes (AA versus GG: OR = 1.24, 95% CI = 1.09-1.42, p = 0.104 for heterogeneity; the A allele carriers versus GG: OR = 1.35, 95% CI = 1.13-1.57, p = 0.219 for heterogeneity). When stratified analysis by ethnicity, significantly increased risks were found among Asians but not in Caucasians. In the subgroup analyses by smoking status, there were no significant association...Continue Reading

References

Sep 1, 1986·Controlled Clinical Trials·R DerSimonian, N Laird
Oct 6, 1997·BMJ : British Medical Journal·M EggerC Minder
Nov 5, 1997·Epidemiology·C RodríguezC W Heath
Feb 26, 2000·Carcinogenesis·J de Boer, J H Hoeijmakers
Apr 4, 2001·Carcinogenesis·D ButkiewiczC C Harris
Mar 8, 2002·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Joel N HirschhornKurt Hirschhorn
Mar 14, 2002·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Jae Yong ParkTae Hoon Jung
Jul 26, 2002·Molecular and Cellular Biology·Joyce T Reardon, Aziz Sancar
Jul 11, 2003·Nature·Jian ChenBeat Suter
Feb 6, 2004·Mutation Research·Ulla VogelOle Raaschou-Nielsen
Jun 17, 2004·Environmental and Molecular Mutagenesis·Carsten HarmsWilliam W Au
Sep 15, 2004·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Z HuH Shen
Dec 24, 2004·American Journal of Epidemiology·Simone Benhamou, Alain Sarasin
Apr 26, 2005·International Journal of Cancer. Journal International Du Cancer·Min ShenQing Lan
Oct 1, 2005·Carcinogenesis·Shanbeh ZienolddinyAage Haugen
May 20, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Chee-Keong TohEng-Huat Tan
Oct 5, 2007·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Ole Raaschou-NielsenUlla Vogel
May 3, 2008·Mayo Clinic Proceedings·Julian R MolinaAlex A Adjei

❮ Previous
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Citations

Jul 17, 2012·Biochemical Genetics·Marta Wlodarczyk, Grazyna Nowicka
Jan 26, 2013·Carcinogenesis·Ariela L Marshall, David C Christiani
Jan 8, 2013·Journal of Experimental & Clinical Cancer Research : CR·Ping ZhanLi-Ke Yu
Dec 4, 2012·International Journal of Molecular Sciences·Janusz BlasiakKai Kaarniranta
Aug 1, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Su-Feng ZhaoEn-Yi Tang
Mar 7, 2014·Hereditary Cancer in Clinical Practice·Andrzej ZylukTadeusz Dębniak
Feb 22, 2014·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Xiang TanMingwu Chen
May 23, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Hai-Ying Wu, Ling-Yu Ding
Aug 13, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Kai-Ge WuXi Huang
Dec 24, 2010·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·David C Christiani
Apr 3, 2012·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Sébastien CouraudPierre-Jean Souquet
Aug 26, 2011·Mutation Research·Fulvio RicceriPaolo Vineis
Jul 1, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ping LiMin-Wen Ha
Dec 15, 2015·Mutation Research. Genetic Toxicology and Environmental Mutagenesis·Nikolai V LitviakovАndrei B Karpov
Apr 19, 2012·International Journal of Cancer. Journal International Du Cancer·Dorota ButkiewiczMarzena Gawkowska-Suwińska
Aug 5, 2014·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Volha P RamaniukRoza I Goncharova
May 24, 2015·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Mi-Sun LeeDavid C Christiani
Jan 1, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Narasimha Reddy ParineMohammed Alanazi
Dec 7, 2010·Molecular Biology Reports·Ya-Nan JiLi-Ke Yu
Sep 24, 2013·Molecular Biology Reports·Su-Feng ZhaoEn-Yi Tang

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