Erectile dysfunction: an overview

Human Reproduction Update
A FabbriA Isidori

Abstract

Erectile dysfunction is a common (affecting 10-20 million men in the USA) and multifactorial disease due to organic and/or psychological factors that strongly impairs the quality of life in man. During the past decade many advances in the understanding of the pathophysiology of erectile dysfunction have been made and new therapeutic strategies have become available. It has been established that an insufficient production of nitric oxide by penile nerve terminals and/or vascular endothelium may result in an impaired erection or complete impotence. Nowadays, intracavernous injection of vasoactive drugs represents a standardized approach for the diagnosis, and the treatment of choice, for erectile dysfunction, but is not widely accepted by the patients. The possibility of treating erectile dysfunction with intraurethral administration of prostaglandin-E1 has recently become available in the USA, and is a therapy more acceptable to the patients. Other noninvasive medical therapies are undergoing evaluation.

Citations

Jan 27, 2005·World Journal of Urology·Bora AltinkilicWolfgang Weidner
Dec 2, 1998·Atencion primaria·J F Menárguez Puche, E M Martínez Bienvenido
Apr 16, 2009·Nitric Oxide : Biology and Chemistry·Anatoly F Vanin
May 22, 2007·Physiology & Behavior·G K Soukhova-O'HareD Gozal
Sep 27, 2005·Clinical Endocrinology·Andrea M IsidoriAndrea Lenzi
Dec 16, 2006·The Journal of Clinical Hypertension·Arthur L Burnett
May 3, 2011·Nitric Oxide : Biology and Chemistry·Alexander A Andreyev-AndriyevskyAnatoly F Vanin
May 30, 2003·Pharmacological Reviews·Noboru Toda, Tomio Okamura
Aug 6, 1999·Journal of Endocrinological Investigation·A FabbriA Isidori
Dec 23, 2020·Archivio italiano di urologia, andrologia : organo ufficiale [di] Società italiana di ecografia urologica e nefrologica·Mohamad MoussaYoussef Fares

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