Erectile function after permanent 125I prostate brachytherapy for localized prostate cancer

Basic and Clinical Andrology
P Njomnang SohEric Huyghe

Abstract

To analyze erectile function in men treated by prostate brachytherapy (PB) for localized prostate cancer. Of a series of 270 sexually active men treated by PB, 241 (89%), mean age 65 yr (range, 43-80 yr), participated in a study on erectile function that was evaluated using the International Index of Erectile Function 5-item (IIEF-5) questionnaire before implantation and by postal survey after a mean follow-up of 36 months (range, 6-70 months). After PB, 27 patients (11%) had no erectile dysfunction (ED), 36 (15%) had mild ED, 58 (24%) had mild to moderate ED, 24 (10%) had moderate ED, 53 (22%) had severe ED and 43 (18%) were not sexually active. In patients with a preimplant IIEF score >12 (cut-off for intercourse with penetration), 73% had a deterioration of erectile function by at least one class after PB. Risk factors for ED after PB were age, preimplant IIEF score and prostate volume. Median time to ED onset was 16 months and was shorter with androgen deprivation (p = 0.007), diabetes (p = 0.03) and age over 55 (p = 0.01). Following PB, the majority of patients progressively develop or major ED after a free interval that may last several months. Ligue Nationale contre le Cancer, France.

References

Oct 27, 2001·Journal of General Internal Medicine·B G BokhourJ A Talcott
Sep 24, 2002·International Journal of Radiation Oncology, Biology, Physics·Subir NagUNKNOWN American Brachytherapy Society
Nov 7, 2002·International Journal of Radiation Oncology, Biology, Physics·John W RobinsonTak Fung
May 6, 2005·International Journal of Impotence Research·J C Cappelleri, R C Rosen
May 14, 2005·International Journal of Radiation Oncology, Biology, Physics·Gregory S MerrickZachariah A Allen
Aug 16, 2005·Urology·Georgina FinneyPhillip Stricker
Mar 3, 2007·International Journal of Radiation Oncology, Biology, Physics·Gerard J van der WielenLuca Incrocci
Nov 23, 2007·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Marc ColonnaBrigitte Tretarre
Mar 24, 2009·International Journal of Radiation Oncology, Biology, Physics·Al V TairaJonathan H Lief
Apr 14, 2009·International Journal of Radiation Oncology, Biology, Physics·Eric HuygheJean Marc Bachaud
Feb 26, 2013·The Journal of Sexual Medicine·John F SullivanJohn P Mulhall

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