Erectile response to hypothalamic stimulation in rats: role of peripheral nerves

The American Journal of Physiology
F GiulianoO Rampin

Abstract

The role of peripheral parasympathetic and sympathetic pathways was explored in erectile responses elicited by hypothalamic medial preoptic area (MPOA) stimulation in adult male anesthetized rats. Under control conditions, MPOA stimulation reliably elicited erectile responses evidenced by an increase of the intracavernous pressure-to-blood pressure ratio. The erectile response was abolished by 1) acute bilateral section of cavernous or pelvic nerves or cauda equina and 2) chronic lesions of pelvic nerves or cauda equina. Acute section of the hypogastric nerve did not significantly decrease the erectile response. The erectile response was significantly depressed after acute or chronic sections of the paravertebral sympathetic chain at the L4-L5 level or chemical sympathectomy with 6-hydroxydopamine. The decrease due to acute sympathetic chain lesion was reversed by bilateral ligation of the external iliac arteries. Accordingly MPOA stimulation elicits erectile responses via 1) activation of the parasympathetic outflow conveyed by the pelvic and cavernous nerves and 2) activation of neural fibers conveyed by the sympathetic pathways. We propose that sympathetic fibers running in the paravertebral sympathetic chain are responsible...Continue Reading

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Citations

Mar 4, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Delphine Behr-RousselFrançois Giuliano
Nov 6, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Juan Carlos Toledo SalasYoshimasa Koyama
May 10, 2018·BMC Urology·Alexander Andreev-AndrievskiyAnfisa Popova
Mar 10, 2000·American Journal of Physiology. Heart and Circulatory Physiology·Y Sato, G J Christ
Jul 15, 2006·The Journal of Sexual Medicine·Rany Shamloul, Rui Wang

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