PMID: 8591071Oct 1, 1995Paper

Erectile response to topical, intraurethral and intracorporal pharmacotherapy in a rat model of spinal cord injury

The Journal of Spinal Cord Medicine
D A RivasS K Salzman

Abstract

In order to compare the erectile response to topical, intraurethral and intracorporal administration of vasoactive substances in neurologically intact and spinal cord injured (SCI) rats, a standard rat model of SCI using impact trauma at the level of T10 was employed, comparing the tumescence of 24 SCI and 25 control rats. Four weeks after SCI, the effect of vasoactive substances on erectile function was evaluated. Under ketamine anesthesia, the penis was exposed and intracorporal pressure (ICP) was monitored using saline infusion cavernosometry through a 24-gauge catheter inserted into one corpus cavernosum. Changes in ICP were recorded in response to the topical and intraurethral (IU) application of minoxidil (0.1 ml, 2% solution) and 2% nitroglycerin (NTG) ointment (0.1 gm), as well as the intracorporal (IC) administration of papaverine (0.0001-0.10 mg/kg). Results indicated that the mean baseline ICP was 8 +/- 5 mmHg for SCI and 9 +/- 4 mmHg for control rats. No response to topical therapy onto the undegloved penis was noted in either SCI or control rats. IU application of minoxidil to the degloved phallus developed ICP greater than that achieved with topical minoxidil; the topical application of NTG was less effective. In ...Continue Reading

Citations

Aug 30, 2001·International Journal of Impotence Research·A Melman
Aug 30, 2001·International Journal of Impotence Research·A L Burnett
Apr 18, 2003·BJU International·M B ChancellorN Yoshimura
Feb 21, 2014·Clinical and Experimental Pharmacology & Physiology·Hasan Hüseyin TavukçuGöksel Sener

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