Eremophilane Sesquiterpenes and Diphenyl Thioethers from the Soil Fungus Penicillium copticola PSU-RSPG138

Journal of Natural Products
Charuwan DaengrotJariya Sakayaroj

Abstract

Four new compounds including two eremophilane sesquiterpenes, penicilleremophilanes A (1) and B (2), as well as two sulfur-containing biphenols, penicillithiophenols A (3) and B (4), were isolated from the soil fungus Penicillium copticola PSU-RSPG138 together with 16 known compounds. Their structures were elucidated by spectroscopic methods. Known sporogen AO-1 exhibited significant antimalarial activity against Plasmodium falciparum with an IC50 value of 1.53 μM and cytotoxic activity to noncancerous (Vero) cell lines with an IC50 value of 4.23 μM. Although compound 1 was approximately half as active against P. falciparum with the IC50 value of 3.45 μM, it showed much weaker cytotoxic activity.

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Citations

Mar 2, 2016·Journal of Natural Products·Zhongbin ChengWenhan Lin
Jun 9, 2016·Journal of Asian Natural Products Research·Li-Zi ZhaoJun-Shan Yang
Jul 20, 2016·Journal of Natural Products·Jimei LiuJungui Dai
Dec 7, 2019·Malaria Journal·Nasir Tajuddeen, Fanie R Van Heerden
Jun 24, 2020·Natural Product Research·Van Giau VoThuc-Huy Duong
Aug 20, 2017·Biological Chemistry·Kamila Tomoko YuyamaWolf-Rainer Abraham
Nov 7, 2020·Natural Product Research·Jiraporn ArunpanichlertJariya Sakayaroj

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