Eremophilane sesquiterpenes from the endophytic fungus Xylaria sp. GDG-102

Natural Product Research
Yan LiangJiangke Qin

Abstract

A new eremophilane sesquiterpene, xylareremophil (1), together with five known eremophilanes, 1α,10α-epoxy-3α-hydroxyeremophil-7(11)-en-12,8β-olide (2), 1,10α,13-trihydroxyeremophil-7(11)-en-12,8-olide (3), 1α,10α-epoxy-13-hydroxyeremophil-7(11)-en-12,8β-olide (4), mairetolides B (5) and G (6) were isolated from the endophytic fungus Xylaria sp. GDG-102 cultured from Sophora tonkinensis. Their structures were elucidated on the basis of spectroscopic data analysis. The absolute configurations of 1 was determined by comparing computed electronic circular dichroism (ECD) and optical rotation (OR) with experimental results. Compounds 1, 5 and 6 showed antibacterial activities against Proteus vulgaris, Micrococcus luteus, Micrococcus lysodeikticus and Bacillus subtilis with MIC values of 25-100 μg/mL.

References

Sep 25, 2004·Journal of Natural Products·Leonard A McDonaldGuy T Carter
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Citations

Jun 24, 2020·Natural Product Research·Van Giau VoThuc-Huy Duong
Oct 25, 2020·The Journal of Antibiotics·Kevin Becker, Marc Stadler
May 1, 2021·Natural Product Research·Yu-Yue QinRui-Yun Yang

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Datasets Mentioned

BETA
KU645984

Methods Mentioned

BETA
circular dichroism
column chromatography

Software Mentioned

MMFF94S
Gaussian

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