Erenumab: A First-in-Class Monoclonal Antibody for Migraine Prevention

The Annals of Pharmacotherapy
Scott G GarlandJohn G Gums

Abstract

Objective: To review the pharmacology, efficacy, and safety of the calcitonin gene-related peptide (CGRP) inhibitor erenumab for migraine preventive therapy. Data Sources: A MEDLINE/PubMed search (January 2000 to January 2019) was conducted using the keywords erenumab-aooe, erenumab, migraine, migraine prophylaxis, migraine prevention, and chronic migraine. Additional articles were identified by hand from references. Study Selection and Data Extraction: We included English-language articles (excluding poster presentations) evaluating erenumab pharmacology, efficacy, or safety in humans for migraine prevention. Data Synthesis: Erenumab is a CGRP inhibitor that inhibits vasodilation in response to acute migraines, which decreases pain perception during the migraine. Erenumab efficacy and safety has only been compared with placebo, but its reduction in monthly migraine days (MMDs) and medication response (≥50% reduction in MMDs) are comparable to current recommended off-label therapies for migraine prevention in short-term treatment studies. Additionally, erenumab is associated with low adverse event burden with no difference found compared with placebo per published clinical trials. Relevance to Patient Care and Clinical Practice...Continue Reading

References

Aug 19, 2004·Journal of Neurology·Hans-Christoph DienerUNKNOWN MIGR-003 Study Group
Jul 22, 2005·International Journal of Clinical Practice·G BussoneS Schwalen
Feb 16, 2007·Headache·Stephen D SilbersteinUNKNOWN Topiramate Chronic Migraine Study Group
Apr 20, 2007·Cephalalgia : an International Journal of Headache·H-C DienerUNKNOWN TOPMAT-MIG-201(TOP-CHROME) Study Group
Feb 26, 2008·Cephalalgia : an International Journal of Headache·S SilbersteinUNKNOWN Task Force of the International Headache Society Clinical Trials Subcommittee
Feb 23, 2010·Lancet Neurology·Peter J Goadsby, Till Sprenger
Jan 23, 2013·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Daniel SerranoRichard B Lipton
Jun 19, 2013·Cephalalgia : an International Journal of Headache·UNKNOWN Headache Classification Committee of the International Headache Society (IHS)
Jan 1, 2014·Journal of Managed Care Pharmacy : JMCP·Zsolt HeppSepideh F Varon
Aug 29, 2014·Cephalalgia : an International Journal of Headache·Zsolt HeppEmily B Devine
Nov 25, 2017·The New England Journal of Medicine·Peter J GoadsbyRobert A Lenz
Feb 24, 2018·Cephalalgia : an International Journal of Headache·David W DodickRobert A Lenz
Apr 25, 2018·Nature Reviews. Neurology·Lars EdvinssonDiana N Krause
Oct 3, 2018·The Journal of Headache and Pain·Todd SchwedtDaniel Mikol

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Citations

Nov 27, 2019·Pharmacological Reviews·Stacy Gelhaus WendellCheng Zhang
Oct 31, 2020·Journal of Pain & Palliative Care Pharmacotherapy·Mark ArmaniousRebecca Jimenez-Sanders
Nov 2, 2019·Clinics in Laboratory Medicine·Hugues Allard-Chamard
Feb 21, 2021·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Maurizio Sessa, Morten Andersen

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