Erenumab (AMG 334), a monoclonal antagonist antibody against the canonical CGRP receptor, does not impair vasodilatory or contractile responses to other vasoactive agents in human isolated cranial arteries

Cephalalgia : an International Journal of Headache
Lena OhlssonL Edvinsson

Abstract

Calcitonin gene-related peptide (CGRP) is a neuronal transmitter present in intracranial sensory nerves, where it is involved in migraine pathophysiology as well as other biological functions. Recently, the fully human monoclonal antibody erenumab (AMG 334), which targets the canonical calcitonin gene-related peptide receptor, showed significant prophylactic efficacy and favourable safety in phase II and III clinical trials for episodic and chronic migraine and is now approved for migraine prevention in several countries. Given that calcitonin gene-related peptide can mediate vasodilation, we investigated the effect of erenumab on vasoactive responses in the presence or absence of various vasodilatory and vasocontractile mediators in a model using isolated human cerebral and meningeal arteries. Ring segments of human isolated cerebral and meningeal arteries were mounted in a sensitive myograph. On arterial segments pre-contracted with 30 mM potassium chloride, vasoactive responses to calcitonin gene-related peptide were studied in the presence of different concentrations of erenumab. At the maximal tested inhibitory concentration of erenumab (100 nM), functional arterial relaxation in response to nicardipine or substance P, and...Continue Reading

References

Jul 21, 1999·Journal of the Autonomic Nervous System·J TajtiL Edvinsson
Dec 4, 2003·European Journal of Pharmacology·Inger Jansen-OlesenLars Edvinsson
Sep 9, 2008·British Journal of Pharmacology·L Edvinsson
Sep 22, 2010·Cephalalgia : an International Journal of Headache·Lars EdvinssonAntoinette MaassenVanDenBrink
Aug 21, 2013·The Journal of Pain : Official Journal of the American Pain Society·Sajedeh EftekhariLars Edvinsson
Oct 8, 2014·Physiological Reviews·F A RussellS D Brain
Oct 4, 2017·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Agustin Melo-CarrilloRami Burstein
Nov 25, 2017·The New England Journal of Medicine·Stephen D SilbersteinErnesto Aycardi
Nov 25, 2017·The New England Journal of Medicine·Peter J GoadsbyRobert A Lenz
Dec 28, 2018·Brain : a Journal of Neurology·Sabrina KhanMessoud Ashina
Feb 21, 2019·Molecular Pain·LuJuan ZhangJoyce Harts Hurley

❮ Previous
Next ❯

Citations

Sep 19, 2019·Cephalalgia : an International Journal of Headache·Karl Messlinger, Antoinette MaassenVanDenBrink
Jan 16, 2020·Brain Sciences·Andrea Carmine BelinLars Edvinsson
Sep 2, 2020·Cephalalgia : an International Journal of Headache·Claudia AltamuraFabrizio Vernieri
Dec 20, 2019·Neurology·David KudrowDaniel D Mikol
Jan 17, 2020·Pharmaceutics·Marco CavacoVera Neves
Nov 11, 2020·The Journal of Headache and Pain·Karin WarfvingeKristian A Haanes
Apr 6, 2021·Frontiers in Neurology·Claudia Altamura, Fabrizio Vernieri
May 27, 2021·Expert Opinion on Drug Safety·Christina I DeligianniMessoud Ashina
Jul 3, 2021·Journal of Clinical Medicine·Magdalena NowaczewskaWojciech Kaźmierczak
Jul 20, 2021·Revue neurologique·L Edvinsson

❮ Previous
Next ❯

Methods Mentioned

BETA
prophylactic

Software Mentioned

GraphPad
GraphPad Prism

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved