Erenumab in the treatment of migraine

Pain Management
Sameer JainStephen D Silberstein

Abstract

Migraine is a highly prevalent neurological pain syndrome, and its management is limited due to side effects posed by current preventive therapies. Calcitonin gene-related peptide (CGRP) plays a crucial role in the pathogenesis of migraine. In recent years, research has been dedicated to the development of monoclonal antibodies against CGRP and CGRP receptors for the treatment of migraine. This review will focus on the first US FDA-approved CGRP-receptor monoclonal antibody developed for the prevention of migraine: erenumab. Two Phase II trials (one for episodic migraine and one for chronic migraine) and two Phase III trials for episodic migraine have been published demonstrating the efficacy and safety of erenumab in the prevention of migraine.

References

Dec 1, 1987·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·L EdvinssonR Uddman
Jan 5, 1995·Biochemical and Biophysical Research Communications·B FlühmannW Born
Apr 16, 1996·Proceedings of the National Academy of Sciences of the United States of America·A E LuebkeI M Dickerson
May 10, 1996·The Journal of Biological Chemistry·N AiyarY Li
Mar 11, 2000·British Journal of Pharmacology·H DoodsW Eberlein
Apr 26, 2002·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Kevin R OliverRaymond G Hill
May 8, 2002·Cephalalgia : an International Journal of Headache·L H LassenJ Olesen
Aug 28, 2002·Biochemical Society Transactions·A C ConnerD R Poyner
Mar 12, 2004·The New England Journal of Medicine·Jes OlesenUNKNOWN BIBN 4096 BS Clinical Proof of Concept Study Group
Apr 30, 2004·The Journal of Comparative Neurology·Andrew M StrassmanDan Levy
Jul 23, 2004·Physiological Reviews·Susan D Brain, Andrew D Grant
Jun 18, 2005·Brain Research. Brain Research Reviews·Theoharis C TheoharidesAphrodite Konstantinidou
Mar 11, 2006·Bioorganic & Medicinal Chemistry Letters·Theresa M WilliamsSamuel L Graham
Aug 25, 2006·Headache·Paul L Durham
May 18, 2007·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·S BenemeiP Geppetti
Dec 12, 2007·Headache·Kevin HawkinsMarcia Rupnow
Mar 18, 2009·Neurologic Clinics·Peter J Goadsby
Mar 24, 2009·Neuroscience·P J GoadsbyP R Holland
Jan 13, 2010·The Journal of Pharmacology and Experimental Therapeutics·Christopher A SalvatoreStefanie A Kane
Oct 13, 2010·Annual Review of Pharmacology and Toxicology·Honghui Zhou, Mary Ann Mascelli
Mar 9, 2011·Cephalalgia : an International Journal of Headache·David J HewittTony W Ho
Jun 15, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Scott C SupowitDonald J Dipette

❮ Previous
Next ❯

Citations

Mar 15, 2019·Current Treatment Options in Neurology·Sameer Jain, Stephen D Silberstein
May 7, 2020·Neurodegenerative Disease Management·Galina VorobeychikAshley Cox
Jan 11, 2021·Headache·Suprat SaelyCindy Kortepeter

❮ Previous
Next ❯

Clinical Trials Mentioned

NCT00797667
NCT02828020
NCT01952574
NCT02066415
NCT02456740
NCT02483585
NCT03096834

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Cephalalgia : an International Journal of Headache
Jes Olesen
Nihon rinsho. Japanese journal of clinical medicine
Y Ikeda, H Takami
Nihon rinsho. Japanese journal of clinical medicine
Yoshifumi Ikeda, H Takami
© 2022 Meta ULC. All rights reserved