ERG and EOG abnormalities in carriers of X-linked retinitis pigmentosa

Eye
P StavrouS J Crews

Abstract

The diagnosis of X-linked retinitis pigmentosa (XL-RP) relies on the identification of the female carriers, in whom fundal abnormalities are often minimal and variable. The electroretinogram (ERG) has been reported as abnormal in 54-96% of heterozygote females. This study examines the combined use of electro-oculogram (EOG) and standardised ERG in 31 obligate and 33 non-obligate carriers of XL-RP. In the obligate carrier group, the EOG was abnormal in 13 carriers (41%), the ERG abnormal in 21 carriers (68%) and a combined EOG and ERG abnormality occurred in 24 carriers (77%). An EOG abnormality alone occurred in 2 carriers (6.5%). Fourteen obligate carriers (45%) showed a peak to peak delay of the ERG scotopic b wave, this being a previously unreported phenomenon. Similarly, in the non-obligate carrier group, the EOG was abnormal in 11 carriers (44%) and the ERG abnormal in 19 carriers (73%). The results of this study suggest that the use of both tests, including measurement of the scotopic b wave latency, may increase the carrier detection rate.

References

May 1, 1978·Archives of Ophthalmology·G A Fishman
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Sep 1, 1986·Archives of Ophthalmology·G A FishmanT T McMahon
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Jul 1, 1983·The British Journal of Ophthalmology·G B ArdenM P Quinlan

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Citations

Dec 6, 2005·Documenta Ophthalmologica. Advances in Ophthalmology·Michael F Marmor, Kathy H C Wu
Sep 7, 2006·Documenta Ophthalmologica. Advances in Ophthalmology·Enzo Maria VingoloEduardo Rispoli
Oct 25, 2003·Progress in Retinal and Eye Research·Enrico M Surace, Alberto Auricchio
Feb 14, 2006·Progress in Retinal and Eye Research·Geoffrey B Arden, Paul A Constable

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