ERG components of negative polarity from the inner retina and the optic nerve response

Documenta Ophthalmologica. Advances in Ophthalmology
Günter Niemeyer

Abstract

ERG components of negative polarity in the light-adapted and in the dark-adapted inner retina are reviewed from a clinical perspective and include consideration of experimental research. Field potentials are inherently complex including summating contributions from specialized neurons as well as from glial elements. This property applies to the PERG, PhNR and to the STR. Experimental research can contribute to identifying the sites/cells of origins i.e. by determining depth profiles and by pharmacological manipulation. Intraretinal microelectrode-studies and pharmacological dissection of light-evoked responses have elucidated the origin of field potentials from the retinal pigment epithelium to the retinal ganglion cells. Thresholds for dark-adapted response components have been compared. Attenuation of the STR by anesthesia was found in cats in vivo when compared to threshold intensities used in isolated eye preparations in vitro, suggestive of depression of inner retinal activity by anesthetics. Evidence has been presented for antidromically elicited retinal responses of negative polarity that resemble the STR and summate with the light-evoked retinal response. This observation supports the notion that negative field potentia...Continue Reading

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Citations

Sep 25, 2007·Documenta Ophthalmologica. Advances in Ophthalmology·Paul J DeMarcoMaureen A McCall
Apr 25, 2013·Reviews in the Neurosciences·Yuyi YouStuart L Graham
Jun 27, 2019·Alternatives to Laboratory Animals : ATLA·Sven SchnichelsStephanie C Joachim
Jun 1, 2013·Journal of Applied Physiology·Andreas SchatzFlorian Gekeler

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