ERG rearrangement in small cell prostatic and lung cancer

Histopathology
Veit SchebleSven Perner

Abstract

Small cell prostatic cancer is a rare but aggressive disease. Currently, its histogenetic origin is unclear and its distinction from metastatic small cell lung cancer is challenging. The aim of our study was to determine whether the ERG rearrangement commonly observed in acinar prostatic cancer can distinguish small cell prostatic cancer from small cell lung cancer samples. We assessed 15 small cell prostatic cancers and 22 small cell lung cancers for ERG rearrangement using fluorescence in situ hybridization. Commonly used and novel immunohistochemical markers (i.e. androgen receptor, calcium activated nucleotidase 1, Golgi phosphoprotein 2, prostate-specific antigen, prostate-specific membrane antigen, CD56, epithelial membrane antigen, thyroid transcription factor 1, chromogranin A, synaptophysin and Ki67) were further studied. ERG rearrangement occurred in 86% of small cell prostatic cancers but in none of the small cell lung cancers and was the best marker to differentiate between both tumours (P < 0.0001). The ERG rearrangement is commonly observed in small cell prostatic cancer, supporting the hypothesis that ERG rearrangement occurs in aggressive prostatic cancers. Furthermore, the ERG rearrangement is the most signific...Continue Reading

References

Feb 15, 1991·Cancer·P G HagoodA B Silverberg
Apr 11, 2000·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·S N AgoffA L Folpe
Oct 29, 2005·Science·Scott A TomlinsArul M Chinnaiyan
Apr 1, 2006·Genes, Chromosomes & Cancer·Maria Johansson SollerIoannis Panagopoulos
May 26, 2006·The American Journal of Surgical Pathology·Jorge L YaoP Anthony di Sant'Agnese
Jul 6, 2006·Neoplasia : an International Journal for Oncology Research·Maisa YoshimotoJeremy A Squire
Oct 13, 2006·Neoplasia : an International Journal for Oncology Research·Nuno CerveiraManuel R Teixeira
Mar 6, 2007·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Rohit MehraRajal B Shah
Apr 3, 2007·Neoplasia : an International Journal for Oncology Research·Kirsten D MertzMark A Rubin
May 29, 2007·The American Journal of Surgical Pathology·Sven PernerMark A Rubin
Jul 20, 2007·Oncogene·G AttardUNKNOWN Transatlantic Prostate Group
Oct 4, 2007·The Journal of Craniofacial Surgery·Wen-lin XiaoNing-yi Li
Dec 29, 2007·The American Journal of Surgical Pathology·Wenle Wang, Jonathan I Epstein
Apr 15, 2008·Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre·Yesim YildirimBulent Celasun
May 5, 2009·European Urology·Scott A TomlinsJack A Schalken
May 26, 2009·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Bo HanRajal B Shah
Jul 3, 2009·Deutsche medizinische Wochenschrift·F SchmidtM A Rubin
Jul 9, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Juan-Miguel MosqueraMartin G Sanda

❮ Previous
Next ❯

Citations

Apr 19, 2011·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Sean R WilliamsonLiang Cheng
Feb 22, 2011·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Tamara L LotanGeorge J Netto
Aug 28, 2012·International Journal of Molecular Medicine·Zaki ShaikhibrahimNicolas Wernert
Nov 26, 2013·Biomarkers in Medicine·Sara Moscovita Falzarano, Cristina Magi-Galluzzi
Oct 1, 2014·Archives of Pathology & Laboratory Medicine·Joshua I WarrickScott A Tomlins
Dec 9, 2014·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Alena BurdovaZdenek Kolar
Jul 10, 2012·Pathology·Adeboye O Osunkoya
Jan 4, 2012·Histopathology·Glen Kristiansen
Jan 4, 2012·Histopathology·Peter A Humphrey
Nov 22, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Himisha BeltranDavid M Nanus
Apr 1, 2017·Current Oncology Reports·Panagiotis J VlachostergiosHimisha Beltran
Feb 6, 2018·Cancer Biomarkers : Section a of Disease Markers·Richard WeitenIsabella Syring
Jul 7, 2012·Virchows Archiv : an International Journal of Pathology·Veit J SchebleSven Perner
Feb 19, 2014·Nature Reviews. Urology·Rosa NadalMario A Eisenberger
May 18, 2010·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Veit J SchebleSven Perner
Jan 4, 2018·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Samson W Fine
Aug 14, 2019·Archives of Pathology & Laboratory Medicine·Varsha Manucha, John Henegan
Jun 14, 2017·Archives of Pathology & Laboratory Medicine·Xiuli XiaoChin-Lee Wu
Apr 9, 2017·Cold Spring Harbor Perspectives in Medicine·Peter A Humphrey
Aug 7, 2019·Archives of Pathology & Laboratory Medicine·Si Kei, Oyedele A Adeyi
Apr 15, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Himisha BeltranMark A Rubin
Feb 12, 2021·Prostate Cancer and Prostatic Diseases·Jacob E BerchuckAna Aparicio
Mar 17, 2021·Gene Reports·Gunnar GottschalkAvik Roy
Feb 11, 2011·Current Opinion in Oncology

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
Veit SchebleSven Perner
Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
Bo HanRajal B Shah
© 2021 Meta ULC. All rights reserved