ERG voltage-gated K+ channels regulate excitability and discharge dynamics of the medial vestibular nucleus neurones.

The Journal of Physiology
Mauro PessiaV E Pettorossi

Abstract

The discharge properties of the medial vestibular nucleus neurones (MVNn) critically depend on the activity of several ion channel types. In this study we show, immunohistochemically, that the voltage-gated K(+) channels ERG1A, ERG1B, ERG2 and ERG3 are highly expressed within the vestibular nuclei of P10 and P60 mice. The role played by these channels in the spike-generating mechanisms of the MVNn and in temporal information processing was investigated electrophysiologically from mouse brain slices, in vitro, by analysing the spontaneous discharge and the response to square-, ramp- and sinusoid-like intracellular DC current injections in extracellular and whole-cell patch-clamp studies. We show that more than half of the recorded MVNn were responsive to ERG channel block (WAY-123,398, E4031), displaying an increase in spontaneous activity and discharge irregularity. The response to step and ramp current injection was also modified by ERG block showing a reduction of first spike latency, enhancement of discharge rate and reduction of the slow spike-frequency adaptation process. ERG channels influence the interspike slope without affecting the spike shape. Moreover, in response to sinusoid-like current, ERG channel block caused f...Continue Reading

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Citations

Feb 19, 2011·Experimental Brain Research·Daniel EugènePierre-Paul Vidal
Aug 19, 2009·Pflügers Archiv : European journal of physiology·Wiebke HirdesChristiane K Bauer
Jun 25, 2010·Pflügers Archiv : European journal of physiology·Anders Peter Larsen
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Aug 20, 2009·The Journal of Biological Chemistry·Alexandre B HardyMichael B Wheeler
Mar 2, 2011·The Journal of General Physiology·Ahleah S Gustina, Matthew C Trudeau
Jan 16, 2013·The Journal of General Physiology·Ahleah S Gustina, Matthew C Trudeau
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Jan 10, 2014·Cancer Medicine·Antonella FioreAnnarosa Arcangeli
Oct 12, 2012·The European Journal of Neuroscience·Silvia FanoUwe Heinemann
Apr 20, 2010·Pharmaceuticals·Annarosa Arcangeli, Andrea Becchetti
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Sep 13, 2018·The Journal of Membrane Biology·Caner Yildirim, Ramazan Bal
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Oct 5, 2021·Neuroreport·Hong Joon LeeSang June Hahn

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