Ergocalciferol promotes in vivo differentiation of keratinocytes and reduces photodamage caused by ultraviolet irradiation in hairless mice

Photodermatology, Photoimmunology & Photomedicine
Hiroaki MitaniT Imanari

Abstract

Ergocalciferol (VD(2)) is usually administered orally and it is metabolized to produce its biologically active metabolites in the liver and kidney. Active vitamin D is a well-known potent regulator of cell growth and differentiation. Active vitamin D such as 1,25-dihydroxyvitamin D(3) (1alpha,25(OH)(2)D(3)) prevents photodamage, including wrinkles and morphologic alterations. However, its clinical and cosmetic use is limited because of its potent, associated effect on calcium metabolism. We examined the efficacy of vitamin D analogues with few adverse effects for preventing skin photodamage. Topical application of VD(2) to hairless mouse dorsal skin, and exposure to solar-simulating ultraviolet (UV) radiation at a dose of 10.8 J/cm(2) (UVA) were performed for 15 weeks, five times a week on weekdays. At the end of the final irradiation, histological and analytical studies were performed. Topical application of VD(2) significantly prevented wrinkle formation and abnormal accumulation of extracellular matrix components. In addition, VD(2) suppressed excessive secretion of IL-6 induced by UV irradiation in cultured human normal keratinocytes, in a dose-dependent manner. VD(2) promoted keratinocytes differentiation in the epidermis ...Continue Reading

References

Jun 1, 1990·The Journal of Investigative Dermatology·A UrbanskiT A Luger
Aug 1, 1987·The Journal of Clinical Investigation·T S KupperU Gubler
Feb 1, 1987·The Journal of Investigative Dermatology·S R PlastowA R Young
Apr 1, 1985·The Journal of Investigative Dermatology·L H KligmanA M Kligman
May 1, 1984·Stain Technology·M KusakabeA Matsukage
Feb 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·L GahringR Daynes
Mar 1, 1984·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S A MobarhanP Miller
Jul 1, 1980·The Tohoku Journal of Experimental Medicine·H KanedaM Imawari
Jan 1, 1995·Skin Pharmacology : the Official Journal of the Skin Pharmacology Society·T KonoR C McKenzie
Aug 1, 1994·Journal of Dermatological Science·J DobakM Dobke
Dec 1, 1995·Toxicology Letters·M I LusterA Bruccoleri
Oct 27, 1997·The Journal of Investigative Dermatology·R L GalloM Bernfield
Jul 17, 1998·The Journal of Investigative Dermatology·L A ApplegateE Frenk
Apr 8, 2000·Skin Pharmacology and Applied Skin Physiology·K LangeM Schäfer-Korting
Mar 26, 2003·The British Journal of Dermatology·M J Boffa
Nov 1, 1990·The Journal of Investigative Dermatology·D N Sauder

❮ Previous
Next ❯

Citations

Jan 1, 2009·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Minh N NguyenRobert C Tuckey
Nov 23, 2011·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Robert C TuckeyWei Li
Mar 2, 2010·Journal of the American Academy of Dermatology·Jamie ZussmanJenny Kim
May 26, 2007·Photodermatology, Photoimmunology & Photomedicine·Hiroaki MitaniChiharu Koide

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.