Ergonomic task reduction prevents bone osteopenia in a rat model of upper extremity overuse

Industrial Health
Mary F BarbeAnn E Barr-Gillespie

Abstract

We evaluated the effectiveness of ergonomic workload reduction of switching rats from a high repetition high force (HRHF) lever pulling task to a reduced force and reach rate task for preventing task-induced osteopenic changes in distal forelimb bones. Distal radius and ulna trabecular structure was examined in young adult rats performing one of three handle-pulling tasks for 12 wk: (1) HRHF, (2) low repetition low force (LRLF); or (3) HRHF for 4 wk and than LRLF thereafter (HRHF-to-LRLF). Results were compared to age-matched controls rats. Distal forelimb bones of 12-wk HRHF rats showed increased trabecular resorption and decreased volume, as control rats. HRHF-to-LRLF rats had similar trabecular bone quality as control rats; and decreased bone resorption (decreased trabecular bone volume and serum CTX1), increased bone formation (increased mineral apposition, bone formation rate, and serum osteocalcin), and decreased osteoclasts and inflammatory cytokines, than HRHF rats. Thus, an ergonomic intervention of HRHF-to-LRLF prevented loss of trabecular bone volume occurring with prolonged performance of a repetitive upper extremity task. These findings support the idea of reduced workload as an effective approach to management of ...Continue Reading

References

Oct 1, 1991·Scandinavian Journal of Work, Environment & Health·L PunnettD B Chaffin
Nov 1, 1986·British Journal of Industrial Medicine·B A SilversteinT J Armstrong
May 1, 1994·Journal of Applied Physiology·S BourrinC Alexandre
May 1, 1993·Medicine and Science in Sports and Exercise·K H MyburghR Marcus
Oct 1, 1996·Mayo Clinic Proceedings·M SinakiR K Gelczer
Sep 1, 1997·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Y UmemuraS Mashiko
Oct 23, 1997·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·D B Burr
Dec 11, 1997·Nuclear Medicine Communications·A M al-NahhasV R McCready
Dec 11, 1999·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·H M Frost
Feb 29, 2000·Medicine and Science in Sports and Exercise·L L Smith
Aug 30, 2000·Bone·C H Turner
Jan 1, 1997·Computer Methods in Biomechanics and Biomedical Engineering·TOR Hildebrand, PETER Rüegsegger
Jul 28, 2001·Exercise and Sport Sciences Reviews·A L HicksD S Ditor
Sep 8, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·A HondaS Nagasawa
Jan 29, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Clinton RubinYi-Xian Qin
Mar 22, 2002·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·C H Turner
Mar 29, 2002·American Journal of Industrial Medicine·Fredric GerrCarolyn Monteilh
Jun 1, 2002·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Ming DingIvan Hvid
Aug 7, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Alexander G RoblingCharles H Turner
Sep 19, 2002·The Journal of Pathology·Osami KudoNicholas A Athanasou
Nov 11, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Ann E BarrMary F Barbe
Jun 11, 2004·The Journal of Orthopaedic and Sports Physical Therapy·Brian D ClarkMary F Barbe
Jun 17, 1950·British Medical Journal·H SELYE
Oct 20, 2004·Journal of Electromyography and Kinesiology : Official Journal of the International Society of Electrophysiological Kinesiology·Christoph AndersWolfgang Schneider
Oct 27, 2004·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Tapio VehmasPäivi Leino-Arjas
Jul 19, 2005·Journal of Biomechanics·Jennifer L SchrieferCharles H Turner
Nov 23, 2006·São Paulo Medical Journal = Revista Paulista De Medicina·Bárbara Juarez AmorimEdwaldo Eduardo Camargo
Mar 31, 2007·Arthritis and Rheumatism·C R RatzlaffM W Koehoorn
Apr 12, 2007·Journal of Occupational and Environmental Medicine·Peter LeVikas Patel
May 9, 2008·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Mary F BarbeAnn E Barr
Apr 2, 2009·Scandinavian Journal of Work, Environment & Health·Karen Messing, Barbara A Silverstein
Jun 25, 2009·Exercise and Sport Sciences Reviews·Sandra K Hunter
Jul 22, 2009·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Shobha RaniJudith Litvin
Sep 11, 2009·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Jane M FedorczykMary F Barbe
Jan 1, 2010·Journal of Occupational and Environmental Medicine·Thomas E BernardPaul E Leaverton
Feb 6, 2010·Scandinavian Journal of Rheumatology·H DingP Leino-Arjas

❮ Previous
Next ❯

Citations

Sep 14, 2017·BMC Musculoskeletal Disorders·Judith E GoldSayed Ali
Jul 21, 2020·Connective Tissue Research·Mary F BarbeSteven N Popoff
Jun 26, 2021·Journal of Hand Therapy : Official Journal of the American Society of Hand Therapists·Caroline W Stegink-JansenApril C Cowan

❮ Previous
Next ❯

Methods Mentioned

BETA
ELISA
protein

Software Mentioned

Force Lever
MatLab
Skyscan CT Analyzer
- Lever
Skyscan NRecon
Force

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.