Ergonovine-induced alterations in coronary flow velocity preceding onset of occlusive spasm in patients without significant coronary artery stenoses

The American Journal of Cardiology
T YamadaG Kajiyama

Abstract

This study examined serial changes in coronary flow velocity to elucidate the dynamic change of coronary circulation during coronary spasm. Twenty patients with variant angina and 27 control patients were studied. Coronary flow velocity was monitored using a Doppler guidewire following intracoronary ergonovine administration. In the control group, diastolic flow velocity either did not change or increased slightly in response to ergonovine. However, in patients with variant angina, 2 patterns of flow velocity alterations were observed. In the first pattern, flow initially increased and then suddenly decreased (16 of 20 patients). In the second pattern, flow gradually decreased (3 of 20 patients). In the remaining patient, the coronary flow alteration could not be detected because of branch spasm. When abnormally high flow velocity was defined as a 100% increase in flow after ergonovine administration within 1 minute, and abnormally low flow velocity was defined as a 50% decrease in flow to diagnose variant angina, sensitivities of 35%, 75%, and 85% were noted if flow was measured 1.0, 2.0, and 3.0 minutes after ergonovine administration, respectively. These abnormal flow velocities were observed before ischemic ST changes appea...Continue Reading

References

Apr 1, 1978·The American Journal of Cardiology·F A HeuplerW C Sheldon
Jan 1, 1979·Circulation·P R CiprianoJ F Silverman
Jan 1, 1977·The American Journal of Cardiology·P R McLaughlinD C Harrison
Sep 1, 1989·Journal of the American College of Cardiology·A HoshioH Mashiba
Oct 1, 1989·The American Journal of Cardiology·B P KimballH E Aldridge
Jan 1, 1980·Catheterization and Cardiovascular Diagnosis·R A Chahine
Aug 1, 1980·The American Journal of Cardiology·F A Heupler
Aug 1, 1980·The American Journal of Cardiology·A Fester
Jan 1, 1980·Catheterization and Cardiovascular Diagnosis·A Fester

❮ Previous
Next ❯

Citations

Aug 20, 2008·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·R J WalhoutE M Buijs
Jun 9, 2005·International Journal of Cardiology·David AdlamAnthony Gershlick
Jan 27, 2016·Circulation·Laxmi S MehtaUNKNOWN American Heart Association Cardiovascular Disease in Women and Special Populations Committee of the Council on Clinical Card

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.