Ergothioneine, an adaptive antioxidant for the protection of injured tissues? A hypothesis

Biochemical and Biophysical Research Communications
Barry HalliwellChester L Drum

Abstract

Ergothioneine (ET) is a diet-derived, thiolated derivative of histidine with antioxidant properties. Although ET is produced only by certain fungi and bacteria, it can be found at high concentrations in certain human and animal tissues and is absorbed through a specific, high affinity transporter (OCTN1). In liver, heart, joint and intestinal injury, elevated ET concentrations have been observed in injured tissues. The physiological role of ET remains unclear. We thus review current literature to generate a specific hypothesis: that the accumulation of ET in vivo is an adaptive mechanism, involving the regulated uptake and concentration of an exogenous natural compound to minimize oxidative damage.

References

Jul 1, 1991·Archives of Biochemistry and Biophysics·D AkanmuB Halliwell
Aug 15, 1990·Archives of Biochemistry and Biophysics·A ArduiniP Hochstein
Feb 13, 1997·Biochemical and Biophysical Research Communications·O I AruomaB Halliwell
Nov 24, 1999·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·O I AruomaN Mahmood
Apr 12, 2003·FEBS Letters·Barry Halliwell
Mar 30, 2005·Proceedings of the National Academy of Sciences of the United States of America·Dirk GründemannEdgar Schömig
Jan 1, 1931·The Biochemical Journal·H B Salt
Aug 26, 2006·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·F FranzoniG Santoro
Jul 10, 2007·Journal of Agricultural and Food Chemistry·Janine EyDirk Taubert
Feb 21, 2008·Archives of Biochemistry and Biophysics·Barry Halliwell
Aug 30, 2008·World Journal of Gastroenterology : WJG·Mei LiPin-Jin Hu
Aug 7, 2009·Reproductive Sciences·Elizabeth TurnerJulie Fisher
Nov 17, 2009·Cell Death and Differentiation·B D Paul, S H Snyder
Mar 9, 2010·Drug Metabolism and Pharmacokinetics·Dorothy Su Lin TohEdmund Jon Deoon Lee
Mar 13, 2010·Pharmaceutical Research·Yukio KatoAkira Tsuji
Apr 28, 2010·Journal of the American Chemical Society·Florian P Seebeck
Oct 26, 2010·Antioxidants & Redox Signaling·Roberto GambinoMaurizio Cassader
Dec 7, 2010·Best Practice & Research. Clinical Obstetrics & Gynaecology·Graham J Burton, Eric Jauniaux
Jul 21, 2011·International Journal of Toxicology·Alexander G SchaussGábor Hirka
Oct 18, 2011·Biochimica Et Biophysica Acta·Irwin K Cheah, Barry Halliwell
Nov 9, 2011·Free Radical Biology & Medicine·Anabela P RoloCarlos M Palmeira
Dec 27, 2011·Preventive Medicine·John E Repine, Nancy D Elkins
Aug 28, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Nae-Cherng YangTuzz-Ying Song
Dec 1, 2012·Biochimica Et Biophysica Acta·Peng YeBarry Halliwell
Mar 19, 2013·Journal of Lipid Research·Maret G Traber
Apr 18, 2013·The Journal of Physical Chemistry. a·Phil De LunaJames W Gauld
May 1, 2013·Antimicrobial Agents and Chemotherapy·Carine Sao EmaniBienyameen Baker

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Citations

Jul 23, 2016·Biochemical and Biophysical Research Communications·Irwin K CheahBarry Halliwell
Jun 13, 2017·Journal of the American Chemical Society·Abayomi S FaponleSam P de Visser
Apr 5, 2017·Journal of Cardiovascular Pharmacology·Luigi ServilloMaria Luisa Balestrieri
Nov 4, 2017·Cardiovascular Diabetology·Etheresia PretoriusDouglas B Kell
Jun 1, 2018·FEBS Letters·Barry HalliwellRichard M Y Tang
Jan 27, 2018·Scientific Reports·Richard Ming Yi TangBarry Halliwell
Jun 13, 2019·Chemistry : a European Journal·Alice MaurerFlorian P Seebeck
Aug 9, 2017·Angewandte Chemie·Reto BurnFlorian P Seebeck
Feb 14, 2020·Nutrition Research Reviews·Irina BorodinaDouglas B Kell
Oct 17, 2018·Proceedings of the National Academy of Sciences of the United States of America·Bruce N Ames
Jul 11, 2020·Antioxidants·Irwin K Cheah, Barry Halliwell
Aug 19, 2020·Journal of Clinical Medicine·Quentin FaucherChantal Barin-Le Guellec
Dec 19, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Salvatore SotgiaArduino A Mangoni
Jan 23, 2018·Frontiers in Medicine·Louise C Kenny, Douglas B Kell
Oct 20, 2020·Frontiers in Cell and Developmental Biology·Lara ConsoleCesare Indiveri
Sep 12, 2020·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Reinaldo MarínLuis Sobrevia
Feb 10, 2021·Redox Biology·Irwin K Cheah, Barry Halliwell
Oct 16, 2020·Free Radical Biology & Medicine·Barry Halliwell
Aug 5, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Ayobami DareAnand Nadar
Oct 24, 2018·Analytical Chemistry·Ae Eun SeokHee-Gyoo Kang
Apr 17, 2018·ACS Chemical Biology·Laëtitia MissonFlorian P Seebeck
Sep 18, 2021·Scientific Reports·William J BehofWellington Pham
Oct 9, 2021·Antioxidants & Redox Signaling·Bindu D Paul
Nov 21, 2017·Kidney International·Yoshitaka Isaka

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