PMID: 9185334May 1, 1997Paper

Ergothioneine distribution in bovine and porcine ocular tissues

Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology
T K ShiresL D Stegink

Abstract

Ergothioneine (ERT), is a low molecular weight, sulfur-containing antioxidant occurring in up to millimolar amounts in mammalian tissues. Using an improved HPLC assay, ERT levels have been measured and compared in bovine and porcine eyes and erythrocytes. The rank order of ERT levels in bovine ocular tissue was lens > retina = cornea > pigmented retinal epithelium (RPE) > aqueous humor (AQ) > vitreous humor (VIT) > sclera. In porcine ocular tissue, the rank order was retina > AQ > VIT > RPE > cornea > lens > sclera. ERT levels in bovine lens were about 250 x > that in porcine lens. Porcine erythrocyte levels were 5.5 x > bovine levels. Species differences were also observed in the retina, VIT and AQ where porcine levels were 2 to 10-fold greater than bovine levels. ERT in bovine lens and cornea was 35 and 14 times greater than the corresponding level of reduced glutathione (GSH). Porcine lens had 45 times more GSH than ERT. Values for ERT and GSH in other tissues from both species were of the same order of magnitude. These results are consistent with a role for ERT in prevention of oxidative damage to the eye.

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Citations

Oct 12, 2012·Applied Microbiology and Biotechnology·Hisashi MuramatsuShinji Nagata
Nov 17, 2009·Cell Death and Differentiation·B D Paul, S H Snyder
Oct 12, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Tuzz-Ying SongMing-Shiun Tsai
Oct 18, 2011·Biochimica Et Biophysica Acta·Irwin K Cheah, Barry Halliwell
Feb 21, 2016·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Jonghwa Lee, Ryan M Pelis
Oct 1, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Salvatore SotgiaAngelo Zinellu
Jun 1, 2018·FEBS Letters·Barry HalliwellRichard M Y Tang
Jan 27, 2018·Scientific Reports·Richard Ming Yi TangBarry Halliwell
Feb 14, 2020·Nutrition Research Reviews·Irina BorodinaDouglas B Kell
Nov 15, 2019·Journal of Biochemistry·Hisashi MuramatsuShinji Nagata
May 29, 2018·Experimental and Therapeutic Medicine·Göksel GökçeElif Ertuna
Nov 5, 2019·Frontiers in Bioengineering and Biotechnology·Steven A van der HoekIrina Borodina
Aug 22, 2017·Physical Chemistry Chemical Physics : PCCP·Katrin PeckelsenMathias Schäfer
Feb 10, 2021·Redox Biology·Irwin K Cheah, Barry Halliwell
Feb 25, 2021·Bioscience, Biotechnology, and Biochemistry·Hisashi MuramatsuShinji Nagata
Jun 6, 2021·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Lalitphan KitsanayanyongToshiaki Ohshima
Sep 18, 2021·Scientific Reports·William J BehofWellington Pham
Oct 9, 2021·Antioxidants & Redox Signaling·Bindu D Paul

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