Erinacine S, a Rare Sesterterpene from the Mycelia of Hericium erinaceus

Journal of Natural Products
Chien-Chih ChenChien-Chang Shen

Abstract

A new sesterterpene, erinacine S, and one cyathane diterpene xyloside, erinacine A, were isolated from the ethanol extract of the mycelia of Hericium erinaceus. Their structures were elucidated by spectroscopic and X-ray analysis. A 30-day oral course of erinacines A and S attenuated Aβ plaque burden in the brains of 5-month-old female APP/PS1 transgenic mice. Moreover, erinacines A and S significantly increased the level of insulin-degrading enzyme in cerebral cortex.

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Citations

Oct 30, 2016·Journal of Natural Products·Lars AndernachTill Opatz
Oct 29, 2017·Journal of Asian Natural Products Research·Yan-Fei Liu, Shi-Shan Yu
Jun 29, 2018·Behavioural Neurology·I-Chen LiChin-Chu Chen
Sep 25, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Li-Yu WangCheng-Hung Chuang
Apr 27, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jun-Hao HuChia-Feng Kuo
Dec 29, 2019·International Journal of Molecular Sciences·Pit Shan ChongLee Wei Lim
Aug 23, 2016·Biomedical Research·Shoko FurutaKuniyoshi Shimizu
Dec 23, 2020·Natural Product Reports·Keke Li, Kirk R Gustafson
Jun 3, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Christian Bailly, Jin-Ming Gao

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